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      Deposition of IgG Anti-Actin Antibodies on Kidneys of Glomerular Nephropathy Patients with an Enhanced Glomerular Alpha Smooth Muscle Actin Expression

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          Abstract

          In this study, we have attempted to evaluate by immunohistochemistry assay the glomerular alpha smooth muscle actin (ASMA) expression in 53 kidney biopsy specimens obtained from patients with glomerular nephropathy as compared with 16 histologically normal human kidneys. An enhanced mesangial ASMA expression was observed in 26 of 53 specimens of patients with glomerulonephritis. In contrast, normal glomeruli showed no ASMA-positive mesangial cells. Furthermore, we have analyzed the specificities of antibodies eluted from kidney biopsy specimens from patients and controls using an enzyme immunoassay against a panel of self antigens composed of actin, myosin, tubulin and DNA. The antibodies eluted from exclusively renal biopsy specimens of patients with an enhanced glomerular ASMA expression showed high IgG activity restricted to actin. Our results demonstrated the presence of IgG anti-actin activity in glomerular nephropathy patients with an enhanced mesangial ASMA expression.

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          Author and article information

          Journal
          Journal ID (publisher-id): NEF
          Journal ID (nlm-ta): Nephron
          Journal ID (doi): 10.1159/issn.1660-8151
          Title: Nephron
          Publisher: S. Karger AG
          ISSN (Print): 1660-8151
          ISSN (Electronic): 2235-3186
          Publication date Subscription-year: 1998
          Publication date (Print): April 1998
          Publication date (Electronic): 26 March 1998
          Volume: 78
          Issue: 4
          Pages: 410-415
          Affiliations
          a Laboratoire d’Immunologie et de Biologie Moléculaire, Faculté de Médecine, Sfax, b Service de Néphrologie, Hôpital Hédi Chaker, Sfax, c Laboratoire d’Anatomie Pathologie, Hôpital Habib Bourguiba, Sfax, d Faculté des Sciences de Sfax, Tunisie
          Article
          Publisher ID: 44969 Other ID: Nephron 1998;78:410–415
          DOI: 10.1159/000044969
          PubMed ID: 9578067
          SO-VID: 510bcf54-2187-4bc2-b9ba-0fb58801f0b5
          Copyright © © 1998 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Figures: 2, Tables: 1, References: 13, Pages: 6
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Cardiovascular Medicine,Nephrology
          Keywords: Alpha smooth muscle actin,Kidney eluates,IgG autoantibodies,Glomerular nephropathy
          Data availability:
          ScienceOpen disciplines: Cardiovascular Medicine, Nephrology
          Keywords: Alpha smooth muscle actin, Kidney eluates, IgG autoantibodies, Glomerular nephropathy

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