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      Deposition of IgG Anti-Actin Antibodies on Kidneys of Glomerular Nephropathy Patients with an Enhanced Glomerular Alpha Smooth Muscle Actin Expression

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          Abstract

          In this study, we have attempted to evaluate by immunohistochemistry assay the glomerular alpha smooth muscle actin (ASMA) expression in 53 kidney biopsy specimens obtained from patients with glomerular nephropathy as compared with 16 histologically normal human kidneys. An enhanced mesangial ASMA expression was observed in 26 of 53 specimens of patients with glomerulonephritis. In contrast, normal glomeruli showed no ASMA-positive mesangial cells. Furthermore, we have analyzed the specificities of antibodies eluted from kidney biopsy specimens from patients and controls using an enzyme immunoassay against a panel of self antigens composed of actin, myosin, tubulin and DNA. The antibodies eluted from exclusively renal biopsy specimens of patients with an enhanced glomerular ASMA expression showed high IgG activity restricted to actin. Our results demonstrated the presence of IgG anti-actin activity in glomerular nephropathy patients with an enhanced mesangial ASMA expression.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1998
          April 1998
          26 March 1998
          : 78
          : 4
          : 410-415
          Affiliations
          a Laboratoire d’Immunologie et de Biologie Moléculaire, Faculté de Médecine, Sfax, b Service de Néphrologie, Hôpital Hédi Chaker, Sfax, c Laboratoire d’Anatomie Pathologie, Hôpital Habib Bourguiba, Sfax, d Faculté des Sciences de Sfax, Tunisie
          Article
          44969 Nephron 1998;78:410–415
          10.1159/000044969
          9578067
          © 1998 S. Karger AG, Basel

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          Page count
          Figures: 2, Tables: 1, References: 13, Pages: 6
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/44969
          Categories
          Original Paper

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