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      Liquid Metal Based Flexible and Implantable Biosensors

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          Abstract

          Biosensors are the core elements for obtaining significant physiological information from living organisms. To better sense life information, flexible biosensors and implantable sensors that are highly compatible with organisms are favored by researchers. Moreover, materials for preparing a new generation of flexible sensors have also received attention. Liquid metal is a liquid-state metallic material with a low melting point at or around room temperature. Owing to its high electrical conductivity, low toxicity, and superior fluidity, liquid metal is emerging as a highly desirable candidate in biosensors. This paper is dedicated to reviewing state-of-the-art applications in biosensors that are expounded from seven aspects, including pressure sensor, strain sensor, gas sensor, temperature sensor, electrical sensor, optical sensor, and multifunctional sensor, respectively. The fundamental scientific and technological challenges lying behind these recommendations are outlined. Finally, the perspective of liquid metal-based biosensors is present, which stimulates the upcoming design of biosensors.

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          Most cited references133

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          Roll-to-roll production of 30-inch graphene films for transparent electrodes.

          The outstanding electrical, mechanical and chemical properties of graphene make it attractive for applications in flexible electronics. However, efforts to make transparent conducting films from graphene have been hampered by the lack of efficient methods for the synthesis, transfer and doping of graphene at the scale and quality required for applications. Here, we report the roll-to-roll production and wet-chemical doping of predominantly monolayer 30-inch graphene films grown by chemical vapour deposition onto flexible copper substrates. The films have sheet resistances as low as approximately 125 ohms square(-1) with 97.4% optical transmittance, and exhibit the half-integer quantum Hall effect, indicating their high quality. We further use layer-by-layer stacking to fabricate a doped four-layer film and measure its sheet resistance at values as low as approximately 30 ohms square(-1) at approximately 90% transparency, which is superior to commercial transparent electrodes such as indium tin oxides. Graphene electrodes were incorporated into a fully functional touch-screen panel device capable of withstanding high strain.
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            Flexible and Stretchable Physical Sensor Integrated Platforms for Wearable Human-Activity Monitoringand Personal Healthcare.

            Flexible and stretchable physical sensors that can measure and quantify electrical signals generated by human activities are attracting a great deal of attention as they have unique characteristics, such as ultrathinness, low modulus, light weight, high flexibility, and stretchability. These flexible and stretchable physical sensors conformally attached on the surface of organs or skin can provide a new opportunity for human-activity monitoring and personal healthcare. Consequently, in recent years there has been considerable research effort devoted to the development of flexible and stretchable physical sensors to fulfill the requirements of future technology, and much progress has been achieved. Here, the most recent developments of flexible and stretchable physical sensors are described, including temperature, pressure, and strain sensors, and flexible and stretchable sensor-integrated platforms. The latest successful examples of flexible and stretchable physical sensors for the detection of temperature, pressure, and strain, as well as their novel structures, technological innovations, and challenges, are reviewed first. In the next section, recent progress regarding sensor-integrated wearable platforms is overviewed in detail. Some of the latest achievements regarding self-powered sensor-integrated wearable platform technologies are also reviewed. Further research direction and challenges are also proposed to develop a fully sensor-integrated wearable platform for monitoring human activity and personal healthcare in the near future.
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              • Record: found
              • Abstract: found
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              Is Open Access

              A highly stretchable, transparent, and conductive polymer

              A polymer is described that is conductive and stretchable, which can lead to electronics that can conform to the human body.
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                Author and article information

                Journal
                Biosensors (Basel)
                Biosensors (Basel)
                biosensors
                Biosensors
                MDPI
                2079-6374
                10 November 2020
                November 2020
                : 10
                : 11
                : 170
                Affiliations
                [1 ]Chinese Academy of Sciences Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Beijing 100190, China; zhangmingkuan17@ 123456mails.ucas.ac.cn (M.Z.); wangxiaohong19@ 123456mails.ucas.ac.cn (X.W.)
                [2 ]Beijing Key Lab of CryoBiomedical Engineering and Key Lab of Cryogenics, Beijing 100190, China
                [3 ]School of Engineering Science, University of Chinese Academy of Sciences, Beijing 100039, China
                [4 ]School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
                [5 ]Department of Mechanical Engineering, Imperial College London, London SW7 2BU, UK; zhiping.huang16@ 123456imperial.ac.uk
                Author notes
                [* ]Correspondence: weirao@ 123456mail.ipc.ac.cn ; Tel.: +86-10-82543719; Fax: +86-10-82543766
                [†]

                These authors contribute equally to the manuscript.

                Author information
                https://orcid.org/0000-0002-4168-0298
                Article
                biosensors-10-00170
                10.3390/bios10110170
                7696291
                33182535
                51121336-7806-4d7b-a217-b1e4ad228ec3
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 14 October 2020
                : 31 October 2020
                Categories
                Review

                liquid metal,biosensor,flexible,implantable,mechanical,gas,temperature,electrical,optical

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