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      Incidence and predictors of post-thyroidectomy hypocalcaemia in a tertiary endocrine surgical unit

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          Abstract

          Background

          Post-thyroidectomy hypocalcaemia is a common complication with significant short and long term morbidity. The aim of this study was to determine the incidence and predictors of post-thyroidectomy hypocalcaemia (as defined by a corrected calcium <2.1 mmol/l) in a tertiary endocrine surgical unit.

          Methods

          A total of 238 consecutive patients who underwent completion or bilateral thyroid surgery between 2008 and 2011 were included in this retrospective study. Clinical and biochemical data were obtained from electronic and hard copy medical records.

          Results

          The incidence of post-thyroidectomy hypocalcaemia on first postoperative day (POD1) was 29.0%. There was variation in the incidence of hypocalcaemia depending on the timing of measurement on the first postoperative day. At six months following surgery, 5.5% of patients were on calcium and/or vitamin D supplementation.

          Factors associated with post-thyroidectomy hypocalcaemia were lower preoperative corrected calcium ( p=0.005) and parathyroid gland (PTG) auto-transplant ( p=0.001). Other clinical factors such as central lymph node dissection, inadvertent PTG excision, ethnicity, preoperative diagnosis and Lugol’s iodine were not associated with post-thyroidectomy hypocalcaemia.

          Conclusion

          The incidence of post-thyroidectomy hypocalcaemia was underestimated by 6% when only POD1 measurements were considered. The timing of measurement on POD1 has an impact on the incidence of post-thyroidectomy hypocalcaemia. Auto-transplantation and lower preoperative calcium were associated with post-thyroidectomy hypocalcaemia.

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          Author and article information

          Contributors
          Journal
          Ann R Coll Surg Engl
          Ann R Coll Surg Engl
          RCSE
          Annals of The Royal College of Surgeons of England
          Royal College of Surgeons
          0035-8843
          1478-7083
          April 2014
          April 2014
          April 2014
          : 96
          : 3
          : 219-223
          Affiliations
          1 Department of Oncology, University of Sheffield, Sheffield, United Kingdom
          2 Endocrine Surgical Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
          Author notes
          Department of Oncology, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK E: ovieedafe@ 123456hotmail.co.uk +44 (0)114 2261379
          Article
          PMC4474053 PMC4474053 4474053 679753
          10.1308/003588414X13814021679753
          4474053
          24780788
          5118e680-db34-4993-932b-1561bda3e95f
          Copyright © 2014, All rights reserved by the Royal College of Surgeons of England
          History
          : 06 December 2013
          Categories
          Endocrine Surgery

          Endocrine surgery,Thyroid surgery,Hypocalcaemia
          Endocrine surgery, Thyroid surgery, Hypocalcaemia

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