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      Leucine Metabolism by Same-Donor Pairs of Human Lenses from Eye Bank Eyes

      Ophthalmic Research

      S. Karger AG

      Age, Eyebank storage, Human lens, Mated pair, Leucine accumulation, Leucine incorporation

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          29 pairs of same-donor human lenses were incubated 6 h in radioactive leucine. The accumulation (CL/CM) and incorporation (cpm/mg protein) were measured. Donor ages were 4–86 years old. The total storage time was recorded. Same-donor (mated) pairs gave highly concordant results for the two members of a pair but there was extreme variability between different pairs, even when the age was comparable. Storage time did not appear to be a significant factor during the first 24 h but beyond that time continued storage led to marked deterioration of lens metabolism. Because of high variability, no significant dependence of metabolism on age was apparent. A consideration of these results along with comparable investigations from the literature leads to the conclusion that differences among individuals are the chief cause of the wide variation among human lenses although there is some evidence that storage conditions may produce a significant effect. It was not possible to derive a normal value for the parameters measured in this investigation.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          04 December 2009
          : 14
          : 6
          : 450-458
          Emory University, Department of Ophthalmology, Atlanta, Ga., USA
          265223 Ophthalmic Res 1982;14:450–458
          © 1982 S. Karger AG, Basel

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          Pages: 9
          Original Paper


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