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      Nrf2 signaling pathway: Pivotal roles in inflammation.

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          Abstract

          Inflammation is the most common feature of many chronic diseases and complications, while playing critical roles in carcinogenesis. Several studies have demonstrated that Nrf2 contributes to the anti-inflammatory process by orchestrating the recruitment of inflammatory cells and regulating gene expression through the antioxidant response element (ARE). The Keap1 (Kelch-like ECH-associated protein)/Nrf2 (NF-E2 p45-related factor 2)/ARE signaling pathway mainly regulates anti-inflammatory gene expression and inhibits the progression of inflammation. Therefore, the identification of new Nrf2-dependent anti-inflammatory phytochemicals has become a key point in drug discovery. In this review, we discuss the members of the Keap1/Nrf2/ARE signal pathway and its downstream genes, the effects of this pathway on animal models of inflammatory diseases, and crosstalk with the NF-κB pathway. In addition we also discuss about the regulation of NLRP3 inflammasome by Nrf2. Besides this, we summarize the current scenario of the development of anti-inflammatory phytochemicals and others that mediate the Nrf2/ARE signaling pathway.

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          Author and article information

          Journal
          Biochim. Biophys. Acta
          Biochimica et biophysica acta
          Elsevier BV
          0006-3002
          0006-3002
          Feb 2017
          : 1863
          : 2
          Affiliations
          [1 ] Department of Biochemistry, School of Medicine, Zhejiang University, Hangzhou 310058, PR China.
          [2 ] Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, PR China; School of Pharmacy, Nantong University, Nantong 226001, PR China.
          [3 ] Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, PR China.
          [4 ] Department of Biochemistry, School of Medicine, Zhejiang University, Hangzhou 310058, PR China. Electronic address: xiuwentang@zju.edu.cn.
          Article
          S0925-4439(16)30286-1
          10.1016/j.bbadis.2016.11.005
          27825853
          511e6579-2f10-4f86-b435-bb0870a36d0b
          History

          ARE,Inflammation,Keap1,Nrf2,Oxidative stress,Phytochemical
          ARE, Inflammation, Keap1, Nrf2, Oxidative stress, Phytochemical

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