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      The emerging role of EpCAM in cancer and stem cell signaling.

      Cancer research

      metabolism, beta Catenin, physiology, Stem Cells, Signal Transduction, Protein Binding, physiopathology, Neoplasms, Models, Biological, Humans, Cell Adhesion Molecules, Antigens, Neoplasm, Animals

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          Abstract

          Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface-binding site for therapeutic antibodies. Recent findings can better explain the relevance of EpCAM's high-level expression on human cancers and cancer propagating cells, and its negative prognostic potential for survival of patients with certain cancers. EpCAM has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

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          Journal
          10.1158/0008-5472.CAN-09-0654
          19584271

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