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      Committed mast cell progenitors in mouse blood differ in maturity between Th1 and Th2 strains

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      Author(s): , ,
      Publication date (Electronic):
      Journal: Allergy
      Publisher: BlackWell Publishing Ltd
      Keywords: blood, mast cell progenitors, mast cells

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          Abstract

          Mast cell progenitors (MCp) leave the bone marrow and migrate to peripheral tissues where they mature. Although the existence of committed MCp in adult mouse and human blood has been postulated, they have never been found. We have isolated a rare population of cells in adult mouse blood, committed to the mast cell lineage. These were identified as lineage − c-kit hi ST2 + integrin β7 hi CD16/32 hi cells. Moreover, a major difference in maturity of these cells based on FcεRI expression was observed between the Th2-prone BALB/c strain and the Th1-prone C57BL/6 strain (66% vs 25% FcεRI +, respectively). Therefore, the choice of mouse strain is critical when studying disease models such as experimental asthma where mast cells and their progenitors are involved.

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          Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis.

          Shin-ichi Mizuno, Michael Gurish, K. Frank Austen … (2005)
          Basophils and mast cells, which are selectively endowed with the high-affinity IgE receptor and mediate a range of adaptive and innate immune responses, have an unknown developmental relationship. Here, by evaluating the expression of the beta7 integrin, a molecule that is required for selective homing of mast cell progenitors (MCPs) to the periphery, we identified bipotent progenitors that are capable of differentiating into either cell type in the mouse spleen. These basophil/mast cell progenitors (BMCPs) gave rise to basophils and mast cells at the single-cell level and reconstituted both mucosal and connective tissue mast cells. We also identified the basophil progenitor (BaP) and the MCP in the bone marrow and the gastrointestinal mucosa, respectively. We further show that the granulocyte-related transcription factor CCAAT/enhancer-binding protein alpha (C/EBPalpha) plays a primary role in the fate decision of BMCPs, being expressed in BaPs but not in MCPs. Thus, circulating basophils and tissue mast cells share a common developmental stage at which their fate decision might be controlled principally by C/EBPalpha.
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            Identification of mast cell progenitors in adult mice.

            Ching-Cheng Chen, Michele Grimbaldeston, Mindy Tsai … (2005)
            It is well known that mast cells are derived from hematopoietic stem cells. However, in adult hematopoiesis, a committed mast cell progenitor has not yet been identified in any species, nor is it clear at what point during adult hematopoiesis commitment to the mast cell lineage occurs. We identified a cell population in adult mouse bone marrow, characterized as Lin(-)c-Kit(+)Sca-1(-)-Ly6c(-)FcepsilonRIalpha(-)CD27(-)beta7(+)T1/ST2+, that gives rise only to mast cells in culture and that can reconstitute the mast cell compartment when transferred into c-kit mutant mast cell-deficient mice. In addition, our experiments strongly suggest that these adult mast cell progenitors are derived directly from multipotential progenitors instead of, as previously proposed, common myeloid progenitors or granulocyte/macrophage progenitors.
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              Identification of a committed precursor for the mast cell lineage.

              H R Rodewald, M Dessing, A Dvorak … (1996)
              Mast cells originate from hematopoietic stem cells, but the mast cell-committed precursor has not been identified. In the study presented here, a cell population in murine fetal blood that fulfills the criteria of progenitor mastocytes was identified. It is defined by the phenotype Thy-1loc-Kithi, contains cytoplasmic granules, and expresses RNAs encoding mast cell-associated proteases but lacks expression of the high-affinity immunoglobulin E receptor. Thy-1loc-Kithi cells generated functionally competent mast cells at high frequencies in vitro but lacked developmental potential for other hematopoietic lineages. When transferred intraperitoneally, this population reconstituted the peritoneal mast cell compartment of genetically mast cell-deficient W/Wv mice to wild-type levels.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Allergy
                Journal ID (iso-abbrev): Allergy
                Journal ID (publisher-id): all
                Title: Allergy
                Publisher: BlackWell Publishing Ltd (Oxford, UK )
                ISSN (Print): 0105-4538
                ISSN (Electronic): 1398-9995
                Publication date (Print): October 2013
                Publication date (Electronic): 21 September 2013
                Volume: 68
                Issue: 10
                Pages: 1333-1337
                Affiliations
                Department of Medical Biochemistry and Microbiology, Uppsala University Uppsala, Sweden
                Author notes
                Correspondence, Jenny Hallgren, Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE-751 23 Uppsala, Sweden., Tel.: +46 18 471 4676, Fax: +46 18 471 4382, E-mail: jenny.hallgren@ 123456imbim.uu.se

                Edited by: Hans-Uwe Simon

                Article
                DOI: 10.1111/all.12223
                PMC ID: 4226387
                PubMed ID: 24112044
                SO-VID: 512e1eb6-ccbd-41bd-b7a6-1edddc498812
                Copyright © © 2013 The Authors. Allergy published by John Wiley & Sons Ltd
                License:

                This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                History
                Date accepted : 14 June 2013
                Categories
                Subject: Brief Communications

                ScienceOpen disciplines: Immunology
                Keywords: blood,mast cell progenitors,mast cells
                Data availability:
                ScienceOpen disciplines: Immunology
                Keywords: blood, mast cell progenitors, mast cells

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