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      Infiltrating Lymphocytes and Antigen Expression in Uveal Melanoma

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          Abstract

          Monoclonal antibodies and flow cytometry were used to study lymphocyte, monocyte and tumor cell antigen expression in uveal melanoma. Forty-one melanomas were studied after various forms of treatment. An antimelanoma antibody, 13A3E, stained 81.7% of the cells. Tumors treated with helium ions or <sup>l25</sup>I plaques had 13A3E staining reduced to 62.5%, p = 0.011. HLA-ABC stained 85.4%, and HLA-DR stained 7.0% of the cells. T cells (CD3 positive) comprised 4.5 % (range 0.1–29.2 %) of total cell population. Natural killer (NK) cells, B cells and macrophages were present in small numbers (mean < 2.5 % in each case). Tumors with numerous T cells ( > 5%), were used for T cell subtype studies. The mean helper/inducer (CD4) to cytotoxic/suppressor (CD8) ratio was 1.00 (range 0.11–3.15). CD8 decreased, and CD4 increased with age in unirradiated tumors (p < 0.02)

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1992
          Publication date (Print): 1992
          Publication date (Electronic): 10 December 2009
          Volume: 24
          Issue: 1
          Pages: 20-26
          Affiliations
          aOcular Oncology Unit, Department of Ophthalmology, bDepartment of Radiation Oncology, and Francis I. Proctor Foundation, University of California, San Francisco, Calif., USA
          Article
          Publisher ID: 267140 Other ID: Ophthalmic Res 1992;24:20–26
          DOI: 10.1159/000267140
          PubMed ID: 1608588
          SO-VID: 514ff534-ba9a-408e-82f9-5b5839a96812
          Copyright © © 1992 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 21 March 1991
          Date accepted : 10 July 1991
          Page count
          Pages: 7
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Tumor-infiltrating lymphocytes,Cytokine,Uveal melanoma,Flow cytometry,Antimelanoma antibody,T cell subtype
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Tumor-infiltrating lymphocytes, Cytokine, Uveal melanoma, Flow cytometry, Antimelanoma antibody, T cell subtype

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