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      Does Presence of Discrete Subaortic Stenosis Alter Diagnosis and Management of Concomitant Valvular Aortic Stenosis?

      case-report

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          Graphical abstract

          Highlights

          • Adults with SM have slower hemodynamic progression and more rapid AS progression.

          • Changes in LVOT velocities are minimal over time.

          • Presence of SM with AS poses challenges in determining hemodynamic significance.

          • In general, surgery should be recommended when AS is severe and symptoms develop.

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          Most cited references16

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          2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease

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            Discrete subaortic stenosis in adults: increased prevalence and slow rate of progression of the obstruction and aortic regurgitation.

            We sought to determine the prevalence and rate of progression of left ventricular outflow tract obstruction (LVOTO) and aortic regurgitation (AR) in adults with discrete subaortic stenosis (DSS).
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              Risk factors for progression of calcific aortic stenosis and potential therapeutic targets.

              Current thought regarding the progression of calcific aortic stenosis (AS) is presented. After summarizing contemporary ideas about AS pathogenesis, the present article examines the factors that may affect disease progression. Data indicate that this process may be accelerated by aortic valve structure, degree of valvular calcification, chronic renal insufficiency and cardiovascular risk factors such as diabetes and dyslipidemia. Finally, the present review discusses potential therapeutic targets to slow AS progression.
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                Author and article information

                Journal
                CASE (Phila)
                CASE (Phila)
                CASE : Cardiovascular Imaging Case Reports
                Elsevier
                2468-6441
                15 February 2019
                April 2019
                15 February 2019
                : 3
                : 2
                : 77-84
                Affiliations
                [a ]Harvard Medical School, Boston, Massachusetts
                [b ]Veterans Affairs Boston Healthcare System, West Roxbury, Massachusetts
                [c ]Boston University Medical Center, Boston, Massachusetts
                Article
                S2468-6441(18)30110-5
                10.1016/j.case.2018.11.007
                6479215
                515852df-a822-451e-ad51-b0af78294500

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Categories
                Subaortic Membrane and Management of A

                valvular aortic stenosis,subaortic membrane(s),discrete subaortic stenosis,dss,left ventricular outflow tract (lvot) obstructions,serial lvot stenoses

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