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      • Record: found
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      Primate Model of Uveoretinitis and Vasculitis/Experimental Autoimmune Uveoretinitis Induced in Cynomolgus Monkeys by Retinal S Antigen

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          Abstract

          Purpose: We aimed to describe the clinical and angiographic changes in an experimental model of autoimmune uveoretinitis and vasculitis in primates. Methods: Six cynomolgus monkeys received a single subcutaneous immunization with 100 µg of human S antigen with complete Freund’s adjuvant. Results: All the animals had a bilateral long-term disease occurring usually in 1 eye approximately 4 weeks after immunization, the second eye being involved 1–5 weeks later. A cyclic course of the disease could be demonstrated by repeated fundus fluorescein angiograms. The initial and principal manifestation consisted in retinal vascular sheathing affecting veins and venules. The more severe forms showed areas of posterior uveoretinitis, dense vitritis and anterior uveitis. Conclusion: A single systemic injection of pure human retinal S antigen could induce a chronic and recurrent ocular disease similar to human retinal vasculitis.

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          Mitral regurgitation: relationship of noninvasive descriptors of right and left ventricular performance to clinical and hemodynamic findings and to prognosis in medically and surgically treated patients.

          P Kligfield, J. S. Borer, C Hochreiter … (1986)
          To determine objective predictors of survival, 53 patients with chronic, hemodynamically severe mitral regurgitation underwent rest and exercise radionuclide cineangiography, echocardiography, treadmill exercise testing, and ambulatory electrocardiographic monitoring before prospective (average 30 month) follow-up. At entry, symptom status correlated best with radionuclide-based right ventricular ejection fraction (RVEF) and left atrial size, while treadmill exercise tolerance correlated best with RVEF during exercise (r = .48, p less than .005). Correspondingly, in 23 patients who underwent cardiac catheterization, pulmonary arterial systolic and wedge pressures were significantly inversely related to RVEF. On the 24 hr ambulatory electrocardiogram, nonsustained ventricular tachycardia was present in 29% of patients, most frequently when both RVEF and left ventricular ejection fraction (LVEF) were subnormal (p = .03 vs other patients). Since entry, 35 patients have been managed without surgery for 9 to 57 months (average 28); three of these who subsequently underwent operation also are among the 21 patients who have undergone mitral valve replacement (MVR). During the average 28 months of observation under medical treatment five of 35 nonoperated patients have died; all five were among the six nonoperated patients with RVEFs of 30% or less at entry, a descriptor that significantly identified those at high mortality risk (p less than .0001 vs patients with RVEFs greater than 30%). All five also were among the eight nonoperated patients with LVEFs of 45% or less (lower limit of normal), a descriptor that also significantly predicted mortality. Three of the 21 patients who underwent surgery have died, all late after MVR. Among operated patients, only age was a predictor of postoperative survival. A trend toward improved survival was found in the patients with depressed right or left ventricular ejection fraction who underwent surgery compared with those who did not.
          Article 0 comments Cited 14 times – based on 0 reviews     Review now
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            Preoperative Predictors of Late Postoperative Outcome among Patients with Nonischemic Mitral Regurgitation with 'High Risk' Descriptors and Comparison with Unoperated Patients

            Detlef Wencker, Jeffrey Borer, Clare Hochreiter … (2000)
            Among patients with chronic nonischemic mitral regurgitation (MR), high short-term mortality risk can be identified by left (LV) and/or right ventricular (RV) ejection fraction (EF) criteria (LVEF ≤45% and/or RVEF ≤30%). Mitral valve replacement or repair (MVR) significantly improves outcome in this subgroup, but predictors of late postoperative survival are not known, and the benefit of MVR has not been defined in patients matched for severity of LV and RV dysfunction. Therefore, prospective assessment of 14 consecutive high risk MR patients was performed before MVR and during 9 years (average) postoperatively to define echocardiographic and radionuclide angiographic predictors of survival; survival also was evaluated in a contemporaneous series of 9 high risk unoperated MR patients, and in subgroups of operated and unoperated patients matched for EF. Of 14 MVR patients, 4 died (3 cardiac: 1 sudden, 2 congestive heart failure). Only preoperative RVEF ≤20% significantly predicted postoperative deaths (rest p = 0.032; exercise p = 0.05). Of 9 unoperated patients, 8 died. Mortality risk of unoperated patients remained higher than that of MVR patients when groups were matched for preoperative LVEF (p = 0.0001). Among patients with RVEF >20%, MVR significantly improved survival versus medical treatment (rest: p < 0.0001, exercise: p = 0.0003). In high risk MR patients, MVR improves survival; preoperative RV performance can define subgroups with different long-term postoperative survival.
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              A Simple and Rapid Method for Isolation of Retinal S Antigen

              J.P. Faure, C. Dorey, J Cozette (1982)
              Article 0 comments Cited 8 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): ORE
                Journal ID (nlm-ta): Ophthalmic Res
                Journal ID (doi): 10.1159/issn.0030-3747
                Title: Ophthalmic Research
                Publisher: S. Karger AG
                ISBN: 978-3-8055-8584-2
                ISBN: 978-3-8055-8585-9
                ISSN (Print): 0030-3747
                ISSN (Electronic): 1423-0259
                Publication date Subscription-year: 2008
                Publication date (Print): April 2008
                Publication date (Electronic): 18 April 2008
                Volume: 40
                Issue: 3-4
                Pages: 181-188
                Affiliations
                aDepartment of Ophthalmology, University Pierre et Marie Curie, Pitié-Salpêtrière Medical School, Assistance Publique, Hôpitaux de Paris, and bCentre de Recherche des Cordeliers, Université Pierre et Marie Curie, UMRS 872, Paris, and cDepartment of Ophthalmology, University of Paris XIII, Créteil, France
                Article
                Publisher ID: 119873 Other ID: Ophthalmic Res 2008;40:181–188
                DOI: 10.1159/000119873
                PubMed ID: 18421236
                SO-VID: 5164b2e8-8c85-41b6-a67e-398015707780
                Copyright © © 2008 S. Karger AG, Basel
                License:

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                Page count
                Figures: 15, References: 15, Pages: 8
                Categories
                Subject: Paper

                ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
                Keywords: Primate,S antigen,Retinal vasculitis,Periphlebitis,Experimental autoimmune uveoretinitis,Fluorescein angiography,Laser photocoagulation,Monkey
                Data availability:
                ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
                Keywords: Primate, S antigen, Retinal vasculitis, Periphlebitis, Experimental autoimmune uveoretinitis, Fluorescein angiography, Laser photocoagulation, Monkey

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