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      Effects of Protein Synthesis Inhibitors on the Negative Feed-Back Effect of Estrogen on LH Release

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      , ,
      Hormone Research in Paediatrics
      S. Karger AG
      Estrogen, LH release, Inhibition of protein synthesis

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          Abstract

          Ovariectomized female rabbits were pretreated with actinomycin D (80 µg/100 g body weight) cycloheximide (300 µg/100g body weight) or chloramphenicol (300 µg/l00 g body weight) 4 h before an intravenous injection of 25 µg of estradiol benzoate. Actinomycin D, cycloheximide and chloramphenicol decreased basal gonadotropin levels, but actinomycin D was less active than chloramphenicol and cycloheximide. Despite this effect on basal levels, such treatment did not prevent the effect of estradiol benzoate on LH release. Moreover, no significant impairment of the LH response to LH-RH was found. The interpretation of experiments using drugs such actinomycin D, cycloheximide or chloramphenicol requires caution; however, one cannot disregard the possibility that the negative feed-back effect of estrogen, in contrast to the positive effect, may not be mediated by RNA-dependent DNA and the protein-synthesizing systems.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1978
          1978
          25 November 2008
          : 9
          : 5
          : 279-291
          Affiliations
          Department of Neurophysiology School of Medicine, Inserm U 176, Bordeaux
          Article
          178923 Horm Res 1978;9:279–291
          10.1159/000178923
          355077
          5168ad75-8065-4960-95a6-42fe8d2ff7de
          © 1978 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 30 January 1977
          : 20 January 1978
          Page count
          Pages: 13
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          LH release,Estrogen,Inhibition of protein synthesis

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