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      Effects of Protein Synthesis Inhibitors on the Negative Feed-Back Effect of Estrogen on LH Release

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      Hormone Research in Paediatrics

      S. Karger AG

      Estrogen, LH release, Inhibition of protein synthesis

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          Ovariectomized female rabbits were pretreated with actinomycin D (80 µg/100 g body weight) cycloheximide (300 µg/100g body weight) or chloramphenicol (300 µg/l00 g body weight) 4 h before an intravenous injection of 25 µg of estradiol benzoate. Actinomycin D, cycloheximide and chloramphenicol decreased basal gonadotropin levels, but actinomycin D was less active than chloramphenicol and cycloheximide. Despite this effect on basal levels, such treatment did not prevent the effect of estradiol benzoate on LH release. Moreover, no significant impairment of the LH response to LH-RH was found. The interpretation of experiments using drugs such actinomycin D, cycloheximide or chloramphenicol requires caution; however, one cannot disregard the possibility that the negative feed-back effect of estrogen, in contrast to the positive effect, may not be mediated by RNA-dependent DNA and the protein-synthesizing systems.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 9
          : 5
          : 279-291
          Department of Neurophysiology School of Medicine, Inserm U 176, Bordeaux
          178923 Horm Res 1978;9:279–291
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 13


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