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      Short-Term Tools to Measure Responsiveness to Growth Hormone Replacement

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          Growth hormone (GH) replacement is a prolonged and expensive treatment modality which involves daily subcutaneous injections in children and adults. Efforts have been made, therefore, to develop short-term tests to predict long-term clinical response. The so-called insulin-like growth factor I (IGF-I) generation test was originally introduced in order to select responders to GH among short children without classical GH deficiency. A positive correlation between short-term increase in serum IGF-I and linear growth has, however, only been reported in a minority of studies. There is no single outcome measure available in GH-deficient adults, and no evidence of a correlation between IGF-I and the effects of GH replacement on factors such as body composition or physical fitness. In conclusion, no reliable short-term test to predict long-term response to GH replacement is available in either children or adults. For safety reasons, however, measurement of serum IGF-I concentrations in GH-deficient patients remains an important means of monitoring during GH replacement.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          17 November 2004
          : 55
          : Suppl 2
          : 40-43
          Medical Department M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus, Denmark
          63473 Horm Res 2001;55(suppl 2):40–43
          © 2001 S. Karger AG, Basel

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          Page count
          Figures: 1, References: 15, Pages: 4
          Sensitivity to Growth Hormone


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