Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults

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Abstract

Antiretroviral therapy (ART) is the cornerstone of prevention and management of HIV infection.

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Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel.

Melanie Thompson, Michael Mugavero, K Rivet Amico … (2012)

After HIV diagnosis, timely entry into HIV medical care and retention in that care are essential to the provision of effective antiretroviral therapy (ART). Adherence to ART is among the key determinants of successful HIV treatment outcome and is essential to minimize the emergence of drug resistance. The International Association of Physicians in AIDS Care convened a panel to develop evidence-based recommendations to optimize entry into and retention in care and ART adherence for people with HIV. A systematic literature search was conducted to produce an evidence base restricted to randomized, controlled trials and observational studies with comparators that had at least 1 measured biological or behavioral end point. A total of 325 studies met the criteria. Two reviewers independently extracted and coded data from each study using a standardized data extraction form. Panel members drafted recommendations based on the body of evidence for each method or intervention and then graded the overall quality of the body of evidence and the strength for each recommendation. Recommendations are provided for monitoring entry into and retention in care, interventions to improve entry and retention, and monitoring of and interventions to improve ART adherence. Recommendations cover ART strategies, adherence tools, education and counseling, and health system and service delivery interventions. In addition, they cover specific issues pertaining to pregnant women, incarcerated individuals, homeless and marginally housed individuals, and children and adolescents, as well as substance use and mental health disorders. Recommendations for future research in all areas are also provided.

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Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial

David Margolis, Juan González-García, Hans-Jürgen Stellbrink … (2017)

Cabotegravir and rilpivirine are antiretroviral drugs in development as long-acting injectable formulations. The LATTE-2 study evaluated long-acting cabotegravir plus rilpivirine for maintenance of HIV-1 viral suppression through 96 weeks.

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Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study.

Jean-Michel Molina, Isabelle Charreau, Bruno Spire … (2017)

Data for on-demand pre-exposure prophylaxis (PrEP) are scarce. We implemented a cohort study to assess its efficacy, safety, and effect on sexual behaviour.

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Author and article information

Journal

Title: JAMA

Abbreviated Title: JAMA

Publisher: American Medical Association (AMA)

ISSN (Print): 0098-7484

Publication date Created: July 24 2018

Publication date (Print): July 24 2018

Volume: 320

Issue: 4

Page: 379

Affiliations

[1 ]University of Alabama at Birmingham

[2 ]University of California San Diego School of Medicine

[3 ]Massachusetts General Hospital and Harvard Medical School, Boston

[4 ]The Alfred Hospital and Monash University, Melbourne, Australia

[5 ]University of California Los Angeles

[6 ]Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts

[7 ]University of California San Diego, La Jolla

[8 ]AIDS Research Consortium of Atlanta, Atlanta, Georgia

[9 ]San Francisco Department of Public Health and University of California San Francisco

[10 ]Emory University Rollins School of Public Health and School of Medicine, Atlanta, Georgia

[11 ]University of North Carolina at Chapel Hill School of Medicine

[12 ]University Hospital of Cologne, Department I of Internal Medicine, Cologne, Germany, and German Center for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany

[13 ]University Hospital Zurich and Institute of Medical Virology, University of Zurich, Zurich, Switzerland

[14 ]University of Paris Diderot and Saint-Louis Hospital, APHP, Paris

[15 ]International Antiviral Society–USA, San Francisco, California

[16 ]University of California San Francisco

Article

DOI: 10.1001/jama.2018.8431

PMC ID: 6415748

PubMed ID: 30043070

SO-VID: 51883579-2d35-437e-b7ad-915243243c8b

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Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults : 2018 Recommendations of the International Antiviral Society–USA Panel

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Abstract

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Most cited references 85

Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel.

Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial

Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study.

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Affiliations

Article

History

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