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      Histological Effects of Epidermal Growth Factor on Eyelids and Cornea in Neonatal Mice

      ,

      Ophthalmic Research

      S. Karger AG

      Epidermal growth factor, Neonatal mice, Eye, Cornea

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          Abstract

          Previous studies have shown that radiolabelled epidermal growth factor (EGF) binds to epidermis and cornea in rats, and that topically applied EGF produces an accelerated hyperplastic epithelial healing response in scarified corneas, but has no effect on the morphology of undamaged corneas of adult rabbits. The present study was designed to determine whether systemically administered EGF modifies the morphological development of the eyelids and corneas of neonatal mice. It was found that EGF-treated mice had premature eyelid separation with advanced keratinization at the eyelid margin. The overall thickness of the cornea was less in mice given EGF, the substantia propria being principally affected. By contrast, the corneal epithelium was significantly thicker in EGF-treated mice. It was concluded that EGF affects both the substantia propria of the cornea and the corneal epithelium in neonatal mice, and that this substance perhaps plays a role in the normal development of these tissues.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1980
          1980
          03 December 2009
          : 12
          : 3
          : 184-191
          Affiliations
          Department of Dental Medicine and Surgery, Faculty of Dental Science, University of Melbourne, Melbourne, Vic.
          Article
          265075 Ophthalmic Res 1980;12:184–191
          10.1159/000265075
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Original Paper

          Vision sciences, Ophthalmology & Optometry, Pathology

          Eye, Cornea, Neonatal mice, Epidermal growth factor

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