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      Modification of polysulfone with phospholipid polymer for improvement of the blood compatibility. Part 1. Surface characterization

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      Biomaterials
      Elsevier BV

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          Abstract

          To improve the surface blood compatibility of polysulfone (PSf) membranes, we prepared novel polymeric additives which have suitable blood compatibility. They were polymers with a phosphorylcholine group, a 2-methacryloyloxyethyl phosphorylcholine (MPC) unit. The MPC polymer could be blended with polysulfone by a solvent evaporation method during membrane processing, and a transparent membrane could be obtained. The mechanical properties of the blend membrane were similar to that of the original PSf membrane. Surface analysis of the blend membrane by X-ray photoelectron spectroscopy and dynamic contact angle measurement revealed that the MPC unit in the polymeric additive was concentrated on the surface of the membrane. The blend membrane significantly reduced plasma protein adsorption compared with that of the PSf membrane.

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          Author and article information

          Journal
          Biomaterials
          Biomaterials
          Elsevier BV
          01429612
          September 1999
          September 1999
          : 20
          : 17
          : 1545-1551
          Article
          10.1016/S0142-9612(99)00052-6
          10482408
          5194b775-6c50-48d1-9172-42d6529c829c
          © 1999

          https://www.elsevier.com/tdm/userlicense/1.0/

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