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      Repurposing of rutin for the inhibition of norovirus replication.

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          Abstract

          Drug repurposing is a strategy employed to circumvent some of the bottlenecks involved in drug development, such as the cost and time needed for developing new molecular entities. Noroviruses cause recurrent epidemics and sporadic outbreaks of gastroenteritis associated with significant mortality and economic costs, but no treatment has been approved to date. Herein, a library of molecules previously used in humans was screened to find compounds with anti-noroviral activity. Antiviral testing for four selected compounds against murine norovirus infection revealed that rutin has anti-murine norovirus activity in cell-based assays.

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          Author and article information

          Affiliations
          [1 ] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA.
          Journal
          Arch. Virol.
          Archives of virology
          Springer Nature
          1432-8798
          0304-8608
          Sep 2015
          : 160
          : 9
          10.1007/s00705-015-2495-y
          10.1007/s00705-015-2495-y
          26112762

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