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      The influence of placental metabolism on fatty acid transfer to the fetus.

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          Abstract

          The factors determining fatty acid transfer across the placenta are not fully understood. This study used a combined experimental and computational modeling approach to explore placental transfer of nonesterified fatty acids and identify the rate-determining processes. Isolated perfused human placenta was used to study the uptake and transfer of 13C-fatty acids and the release of endogenous fatty acids. Only 6.2 ± 0.8% of the maternal 13C-fatty acids taken up by the placenta was delivered to the fetal circulation. Of the unlabeled fatty acids released from endogenous lipid pools, 78 ± 5% was recovered in the maternal circulation and 22 ± 5% in the fetal circulation. Computational modeling indicated that fatty acid metabolism was necessary to explain the discrepancy between uptake and delivery of 13C-fatty acids. Without metabolism, the model overpredicts the fetal delivery of 13C-fatty acids 15-fold. Metabolic rate was predicted to be the main determinant of uptake from the maternal circulation. The microvillous membrane had a greater fatty acid transport capacity than the basal membrane. This study suggests that incorporation of fatty acids into placental lipid pools may modulate their transfer to the fetus. Future work needs to focus on the factors regulating fatty acid incorporation into lipid pools.

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          Author and article information

          Journal
          J. Lipid Res.
          Journal of lipid research
          American Society for Biochemistry & Molecular Biology (ASBMB)
          1539-7262
          0022-2275
          Feb 2017
          : 58
          : 2
          Affiliations
          [1 ] Faculty of Engineering and Environment, University of Southampton, SO17 1BJ, UK.
          [2 ] Institute for Life Sciences Southampton, University of Southampton, SO17 1BJ, UK.
          [3 ] Department of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, Austria.
          [4 ] Bioengineering Research Group, Faculty of Medicine, University of Southampton, SO17 1BJ, UK.
          [5 ] Faculty of Engineering and Environment, University of Southampton, SO17 1BJ, UK B.G.Sengers@soton.ac.uk.
          Article
          jlr.P072355
          10.1194/jlr.P072355
          5282960
          27913585
          51ac0055-8fdf-46e2-8627-25cecd466c6a
          History

          placenta,lipid computational model,fatty acids,dual placental perfusion,compartmental modelling,placental transport

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