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      Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.

      Advanced Drug Delivery Reviews

      Animals, Drug Delivery Systems, Drug Design, Humans, Ligands, Magnetic Resonance Imaging, methods, Magnetics, Nanoparticles, Nanotechnology

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          Abstract

          Magnetic nanoparticles (MNPs) represent a class of non-invasive imaging agents that have been developed for magnetic resonance (MR) imaging. These MNPs have traditionally been used for disease imaging via passive targeting, but recent advances have opened the door to cellular-specific targeting, drug delivery, and multi-modal imaging by these nanoparticles. As more elaborate MNPs are envisioned, adherence to proper design criteria (e.g. size, coating, molecular functionalization) becomes even more essential. This review summarizes the design parameters that affect MNP performance in vivo, including the physicochemical properties and nanoparticle surface modifications, such as MNP coating and targeting ligand functionalizations that can enhance MNP management of biological barriers. A careful review of the chemistries used to modify the surfaces of MNPs is also given, with attention paid to optimizing the activity of bound ligands while maintaining favorable physicochemical properties. Copyright 2009 Elsevier B.V. All rights reserved.

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          Author and article information

          Journal
          19909778
          2827645
          10.1016/j.addr.2009.11.002

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