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Abstract
This paper is the fortieth consecutive installment of the annual anthological review
of research concerning the endogenous opioid system, summarizing articles published
during 2017 that studied the behavioral effects of molecular, pharmacological and
genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate
agonists and antagonists. The review is subdivided into the following specific topics:
molecular-biochemical effects and neurochemical localization studies of endogenous
opioids and their receptors (1), the roles of these opioid peptides and receptors
in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive
effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance
and dependence (5), stress and social status (6), learning and memory (7), eating
and drinking (8), drug abuse and alcohol (9), sexual activity and hormones, pregnancy,
development and endocrinology (10), mental illness and mood (11), seizures and neurologic
disorders (12), electrical-related activity and neurophysiology (13), general activity
and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular
responses (16), respiration and thermoregulation (17), and immunological responses
(18).