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      Adult consequences of growth failure in early childhood 1 2 3

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          Abstract

          Background: Growth failure is associated with adverse consequences, but studies need to control adequately for confounding.

          Objective: We related height-for-age z scores (HAZs) and stunting at age 24 mo to adult human capital, marriage, fertility, health, and economic outcomes.

          Design: In 2002–2004, we collected data from 1338 Guatemalan adults (aged 25–42 y) who were studied as children in 1969–1977. We used instrumental variable regression to correct for estimation bias and adjusted for potentially confounding factors.

          Results: A 1-SD increase in HAZ was associated with more schooling (0.78 grades) and higher test scores for reading and nonverbal cognitive skills (0.28 and 0.25 SDs, respectively), characteristics of marriage partners (1.39 y older, 1.02 grade more schooling, and 1.01 cm taller) and, for women, a higher age at first birth (0.77 y) and fewer number of pregnancies and children (0.63 and 0.43, respectively). A 1-SD increase in HAZ was associated with increased household per capita expenditure (21%) and a lower probability of living in poverty (10 percentage points). Conversely, being stunted at 2 y was associated with less schooling, a lower test performance, a lower household per capita expenditure, and an increased probability of living in poverty. For women, stunting was associated with a lower age at first birth and higher number of pregnancies and children. There was little relation between either HAZ or stunting and adult health.

          Conclusion: Growth failure in early life has profound adverse consequences over the life course on human, social, and economic capital.

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          Most cited references18

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          Maternal and child undernutrition and overweight in low-income and middle-income countries

          The Lancet, 382(9890), 427-451
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            An introduction to instrumental variables for epidemiologists.

            Instrumental-variable (IV) methods were invented over 70 years ago, but remain uncommon in epidemiology. Over the past decade or so, non-parametric versions of IV methods have appeared that connect IV methods to causal and measurement-error models important in epidemiological applications. This paper provides an introduction to those developments, illustrated by an application of IV methods to non-parametric adjustment for non-compliance in randomized trials.
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              Effect of a nutrition intervention during early childhood on economic productivity in Guatemalan adults.

              Substantial, but indirect, evidence suggests that improving nutrition in early childhood in developing countries is a long-term economic investment. We investigated the direct effect of a nutrition intervention in early childhood on adult economic productivity. We obtained economic data from 1424 Guatemalan individuals (aged 25-42 years) between 2002 and 2004. They accounted for 60% of the 2392 children (aged 0-7 years) who had been enrolled in a nutrition intervention study during 1969-77. In this initial study, two villages were randomly assigned a nutritious supplement (atole) for all children and two villages a less nutritious one (fresco). We estimated annual income, hours worked, and average hourly wages from all economic activities. We used linear regression models, adjusting for potentially confounding factors, to assess the relation between economic variables and exposure to atole or fresco at specific ages between birth and 7 years. Exposure to atole before, but not after, age 3 years was associated with higher hourly wages, but only for men. For exposure to atole from 0 to 2 years, the increase was US$0.67 per hour (95% CI 0.16-1.17), which meant a 46% increase in average wages. There was a non-significant tendency for hours worked to be reduced and for annual incomes to be greater for those exposed to atole from 0 to 2 years. Improving nutrition in early childhood led to substantial increases in wage rates for men, which suggests that investments in early childhood nutrition can be long-term drivers of economic growth.
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                Author and article information

                Journal
                Am J Clin Nutr
                Am. J. Clin. Nutr
                ajcn
                The American Journal of Clinical Nutrition
                American Society for Nutrition
                0002-9165
                1938-3207
                November 2013
                4 September 2013
                : 98
                : 5
                : 1170-1178
                Affiliations
                [1 ]From the Poverty, Health and Nutrition Division, International Food Policy Research Institute, Washington, DC (JH and ARQ); the Departments of Economics and Sociology, University of Pennsylvania, Philadelphia, PA (JRB); the Department of Economics, Middlebury College, Middlebury, VT (JAM); The Institute of Nutrition of Central America and Panama, Guatemala City, Republic of Guatemala (PM and MR-Z); and the Hubert Department of Global Health, Rollins School of Public Health (ADS, KMY, and RM), and the Department of Sociology (KMY), Emory University, Atlanta, GA.
                Author notes
                [2]

                Supported by the NIH (grants TW-05598 and HD-046125), the National Science Foundation/Economics (grants SES 0136616 and SES 0211404), and Grand Challenges Canada (grant 0072-03). This is a free access article, distributed under terms ( http://www.nutrition.org/publications/guidelines-and-policies/license/) that permit unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                [3 ]Address correspondence to R Martorell, Hubert Department of Global Health, Rollins School of Public Health, Emory University, 1599 Clifton Road, Atlanta, GA 30322. E-mail: rmart77@ 123456emory.edu .
                Article
                064584
                10.3945/ajcn.113.064584
                3798075
                24004889
                51e7abdd-18a4-4064-8c56-51081eb8c243
                © 2013 American Society for Nutrition

                This is a free access article, distributed under terms ( http://www.nutrition.org/publications/guidelines-and-policies/license/) that permit unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 25 April 2013
                : 6 August 2013
                Page count
                Pages: 9
                Categories
                Nutritional Status, Dietary Intake, and Body Composition

                Nutrition & Dietetics
                Nutrition & Dietetics

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