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      Multiple Synchronous Outbreaks of Puumala Virus, Germany, 2010

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          Abstract

          To investigate 2,017 cases of hantavirus disease in Germany, we compared 38 new patient-derived Puumala virus RNA sequences identified in 2010 with bank vole–derived small segment RNA sequences. The epidemic process was driven by outbreaks of 6 Puumala virus clades comprising strains of human and vole origin. Each clade corresponded to a different outbreak region.

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          Is Open Access

          Hantavirus in African Wood Mouse, Guinea

          Hantaviruses are rodentborne, emerging viruses that cause life-threatening human diseases in Eurasia and the Americas. We detected hantavirus genome sequences in an African wood mouse (Hylomyscus simus) captured in Sangassou, Guinea. Sequence and phylogenetic analyses of the genetic material demonstrate a novel hantavirus species, which we propose to name "Sangassou virus."
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            Fragmentation of Landscape as a Cause for Genetic Subdivision in Bank Voles

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              Hantaviruses: immunology, treatment, and prevention.

              Hantaviruses are rodent-borne bunyaviruses that are associated with two main clinical diseases in humans: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. It has been suggested that host-related immune mechanisms rather than direct viral cytopathology may be responsible for the principal abnormality (vascular dysfunction) in these syndromes. This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.
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                Author and article information

                Journal
                Emerg Infect Dis
                Emerging Infect. Dis
                EID
                Emerging Infectious Diseases
                Centers for Disease Control and Prevention
                1080-6040
                1080-6059
                September 2012
                : 18
                : 9
                : 1461-1464
                Affiliations
                [1]Charité Medical School and Labor Berlin Charité-Vivantes GmbH, Berlin, Germany (J. Ettinger, J. Hofmann, B. Klempa, D.H. Kruger);
                [2]Institute of Virology, Infectious Diseases, and Epidemiology, Stuttgart, Germany (M. Enders, F. Tewald);
                [3]Baden-Wuerttemberg State Health Office, Stuttgart (R.M. Oehme);
                [4]Friedrich-Loeffler Institut, Greifswald, Germany (U.M. Rosenfeld, H.S. Ali, M. Schlegel, R.G. Ulrich);
                [5]Bundeswehr Institute of Microbiology, Munich, Germany (S. Essbauer, A. Osterberg);
                [6]Institute for Plant Protection in Horticulture and Forestry, Münster, Germany (J. Jacob, D. Reil);
                [7]and Slovak Academy of Sciences, Bratislava, Slovakia (B. Klempa)
                Author notes
                Address for correspondence: Detlev H. Kruger, Institute of Medical Virology, Helmut-Ruska-Haus, Charité Medical School, Charitéplatz 1, 10117 Berlin, Germany; email: detlev.kruger@ 123456charite.de
                Article
                11-1447
                10.3201/eid1809.111447
                3437711
                22932394
                51f35228-7f88-4032-9db1-885fe780d580
                History
                Categories
                Dispatch
                Dispatch

                Infectious disease & Microbiology
                molecular epidemiology,viruses,puumala virus,hantavirus outbreak,hantavirus,hemorrhagic fever with renal syndrome,germany,hfrs

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