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      The biology, function, and biomedical applications of exosomes

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      Science
      American Association for the Advancement of Science (AAAS)

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          Abstract

          The study of extracellular vesicles (EVs) has the potential to identify unknown cellular and molecular mechanisms in intercellular communication and in organ homeostasis and disease. Exosomes, with an average diameter of ~100 nanometers, are a subset of EVs. The biogenesis of exosomes involves their origin in endosomes, and subsequent interactions with other intracellular vesicles and organelles generate the final content of the exosomes. Their diverse constituents include nucleic acids, proteins, lipids, amino acids, and metabolites, which can reflect their cell of origin. In various diseases, exosomes offer a window into altered cellular or tissue states, and their detection in biological fluids potentially offers a multicomponent diagnostic readout. The efficient exchange of cellular components through exosomes can inform their applied use in designing exosome-based therapeutics.

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          Author and article information

          Journal
          Science
          Science
          American Association for the Advancement of Science (AAAS)
          0036-8075
          1095-9203
          February 06 2020
          February 07 2020
          February 06 2020
          February 07 2020
          : 367
          : 6478
          : eaau6977
          Article
          10.1126/science.aau6977
          7717626
          32029601
          51f73b9d-6566-4b67-8ff6-0282bd5aa842
          © 2020

          http://www.sciencemag.org/about/science-licenses-journal-article-reuse

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