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      Thyroid disrupting chemicals in plastic additives and thyroid health.

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          Abstract

          The globally escalating thyroid nodule incidence rates may be only partially ascribed to better diagnostics, allowing for the assessment of environmental risk factors on thyroid disease. Endocrine disruptors or thyroid-disrupting chemicals (TDC) like bisphenol A, phthalates, and polybrominated diphenyl ethers are widely used as plastic additives in consumer products. This comprehensive review studied the magnitude and uncertainty of TDC exposures and their effects on thyroid hormones for sensitive subpopulation groups like pregnant women, infants, and children. Our findings qualitatively suggest the mixed, significant (α = 0.05) TDC associations with natural thyroid hormones (positive or negative sign). Future studies should undertake systematic meta-analyses to elucidate pooled TDC effect estimates on thyroid health indicators and outcomes.

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          Author and article information

          Journal
          J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
          Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews
          1532-4095
          1059-0501
          2012
          : 30
          : 2
          Affiliations
          [1 ] Water and Health Laboratory, Cyprus International Institute for Environmental and Public Health in association with Harvard School of Public Health, Cyprus University of Technology, Limassol, Cyprus.
          10.1080/10590501.2012.681487
          22690712

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