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      Association of neurotropic viruses in HIV-infected individuals who died of secondary complications of tuberculosis, cryptococcosis, or toxoplasmosis in South India.

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          Abstract

          The frequencies of 10 opportunistic DNA viruses were determined by multiplex real-time PCR in paired cerebrospinal fluid (CSF) and brain tissue of HIV-infected individuals. In the CSF, viruses were detectable in 45/55 cases: JC virus (JCV) in 62%, Epstein-Barr virus (EBV) in 44%, cytomegalovirus (CMV) in 25%, varicella-zoster virus (VZV) in 3.6%, herpes simplex virus 1 (HSV-1) in 1.8%, and human herpesvirus 6 (HHV-6) in 1.8% of cases. A single virus was detectable in 20 cases, 19 cases had coinfection with two viruses, and 6 cases were positive for three viruses. JCV was detectable in the CSF of 62% of cases and in 42% of brain tissues, with higher loads in progressive multifocal leukoencephalopathy (PML) (P < 0.05).

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          Author and article information

          Journal
          J. Clin. Microbiol.
          Journal of clinical microbiology
          1098-660X
          0095-1137
          Mar 2013
          : 51
          : 3
          Affiliations
          [1 ] Department of Clinical Virology, Christian Medical College, Vellore, India. kannangair@cmcvellore.ac.in
          Article
          JCM.03321-12
          10.1128/JCM.03321-12
          3592081
          23284020
          520fa2eb-5d76-419f-9564-0d3943c1d9f3
          History

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