Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype.

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Abstract

Hemolytic uremic syndrome (HUS) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment. Most childhood cases are caused by Shiga toxin-producing bacteria. The other form, atypical HUS (aHUS), accounts for 10% of cases and has a poor prognosis. Genetic complement abnormalities have been found in aHUS.

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PubMed ID:: 20595690

PMC ID:: 2974386

DOI:: 10.2215/CJN.02210310

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Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype.

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