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      Central mechanisms of pathological pain.

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      Nature medicine
      Springer Science and Business Media LLC

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          Abstract

          Chronic pain is a major challenge to clinical practice and basic science. The peripheral and central neural networks that mediate nociception show extensive plasticity in pathological disease states. Disease-induced plasticity can occur at both structural and functional levels and is manifest as changes in individual molecules, synapses, cellular function and network activity. Recent work has yielded a better understanding of communication within the neural matrix of physiological pain and has also brought important advances in concepts of injury-induced hyperalgesia and tactile allodynia and how these might contribute to the complex, multidimensional state of chronic pain. This review focuses on the molecular determinants of network plasticity in the central nervous system (CNS) and discusses their relevance to the development of new therapeutic approaches.

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          Author and article information

          Journal
          Nat Med
          Nature medicine
          Springer Science and Business Media LLC
          1546-170X
          1078-8956
          Nov 2010
          : 16
          : 11
          Affiliations
          [1 ] Pharmacology Institute, University of Heidelberg, Im Neuenheimer Feld, 366 Heidelberg, Germany. rohini.kuner@pharma.uni-heidelberg.de
          Article
          nm.2231
          10.1038/nm.2231
          20948531
          5225b404-381f-4b51-b267-d0150bd092fe
          History

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