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Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial.
James Shepherd
1 ,
Gerard J Blauw ,
Michael B Murphy ,
Edward L E M Bollen ,
Brendan M Buckley ,
Stuart M Cobbe ,
Ian Ford ,
Allan Gaw ,
Michael Hyland ,
J Wouter Jukema ,
Adriaan M Kamper ,
Peter W Macfarlane ,
A Edo Meinders ,
John Norrie ,
Chris J Packard ,
Ivan J Perry ,
David J Stott ,
Brian J Sweeney ,
Cillian Twomey ,
Rudi G J Westendorp
Nov 23 2002
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Abstract
Although statins reduce coronary and cerebrovascular morbidity and mortality in middle-aged individuals, their efficacy and safety in elderly people is not fully established. Our aim was to test the benefits of pravastatin treatment in an elderly cohort of men and women with, or at high risk of developing, cardiovascular disease and stroke.