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      Impact of coffee on liver diseases: a systematic review.

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          Abstract

          Coffee is one of the most commonly consumed beverages in the world. Its health benefits including improved overall survival have been demonstrated in a variety of disease states. To examine the association of coffee consumption with liver disease, a systematic review of studies on the effects of coffee on liver associated laboratory tests, viral hepatitis, nonalcoholic fatty liver disease (NAFLD), cirrhosis and hepatocellular carcinoma (HCC) was performed. Coffee consumption was associated with improved serum gamma glutamyltransferase, aspartate aminotransferase and alanine aminotransferase values in a dose dependent manner in individuals at risk for liver disease. In chronic liver disease patients who consume coffee, a decreased risk of progression to cirrhosis, a lowered mortality rate in cirrhosis patients, and a lowered rate of HCC development were observed. In chronic hepatitis C patients, coffee was associated with improved virologic responses to antiviral therapy. Moreover, coffee consumption was inversely related to the severity of steatohepatitis in patients with non-alcoholic fatty liver disease. Therefore, in patients with chronic liver disease, daily coffee consumption should be encouraged.

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          Author and article information

          Journal
          Liver Int
          Liver international : official journal of the International Association for the Study of the Liver
          Wiley
          1478-3231
          1478-3223
          Apr 2014
          : 34
          : 4
          Affiliations
          [1 ] Department of Medicine, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA, USA; Department of Surgery, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA, USA.
          Article
          10.1111/liv.12304
          24102757
          52343ab0-be99-4118-b9f5-732b6c4d33b9
          © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
          History

          coffee,liver disease
          coffee, liver disease

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