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      New aristolochic acid, aristololactam and renal cytotoxic constituents from the stem and leaves of Aristolochia contorta.

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          Abstract

          Two novel phenanthrene derivatives, aristololactam IVa (1) and 9-hydroxy aristolochic acid I (2) were isolated from the stem and leaves of Anstolochia contorta Bunge, together with 17 known compounds (3-19). The structures of these compounds were determined by spectroscopic analysis. The phenanthrenes obtained were tested for cytotoxicity against renal proximal tubular epithelial cell line (HK-2). Aristololactam IVa and 7-methoxy aristololactam IV were found to have strong cytotoxic activity against HK-2 cells with a potency similar to or even stronger than those of aristolochic acid I and aristololactam I.

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          Author and article information

          Journal
          Pharmazie
          Die Pharmazie
          0031-7144
          0031-7144
          Oct 2005
          : 60
          : 10
          Affiliations
          [1 ] Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China.
          Article
          16259129
          523638c5-b588-4423-9ab1-be419a968de2
          History

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