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      Component-resolved analysis of IgA, IgE, and IgG4 during egg OIT identifies markers associated with sustained unresponsiveness.

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          Abstract

          In a previously reported CoFAR study, 55 subjects with egg allergy underwent randomized, placebo-controlled egg oral immunotherapy (eOIT). Active treatment induced desensitization in most and sustained unresponsiveness (SU) in a smaller subset. We hypothesized that component-resolved analysis of IgE, IgG4, IgA, IgA1, and IgA2 may identify potential biomarkers of SU in OIT subjects.

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          Author and article information

          Journal
          Allergy
          Allergy
          Wiley-Blackwell
          1398-9995
          0105-4538
          Nov 2016
          : 71
          : 11
          Affiliations
          [1 ] University of North Carolina School of Medicine, Chapel Hill, NC, USA.
          [2 ] Duke University Medical Center, Durham, NC, USA.
          [3 ] University of North Carolina School of Medicine, Chapel Hill, NC, USA. mike.kulis@unc.edu.
          [4 ] The EMMES Corporation, Rockville, MD, USA.
          [5 ] University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, AR, USA.
          [6 ] Johns Hopkins University School of Medicine, Baltimore, MD, USA.
          [7 ] Icahn School of Medicine at Mt. Sinai, New York, NY, USA.
          [8 ] National Jewish Health, Denver, CO, USA.
          Article
          NIHMS801823
          10.1111/all.12895
          5035709
          27015954

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