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      Regulation of synaptic connectivity by glia.

      1 ,
      Nature
      Springer Science and Business Media LLC

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          Abstract

          The human brain contains more than 100 trillion (10(14)) synaptic connections, which form all of its neural circuits. Neuroscientists have long been interested in how this complex synaptic web is weaved during development and remodelled during learning and disease. Recent studies have uncovered that glial cells are important regulators of synaptic connectivity. These cells are far more active than was previously thought and are powerful controllers of synapse formation, function, plasticity and elimination, both in health and disease. Understanding how signalling between glia and neurons regulates synaptic development will offer new insight into how the nervous system works and provide new targets for the treatment of neurological diseases.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          1476-4687
          0028-0836
          Nov 11 2010
          : 468
          : 7321
          Affiliations
          [1 ] Cell Biology Department, Box 3709, Duke University Medical Center, Durham, North Carolina 27710, USA. c.eroglu@cellbio.duke.edu
          Article
          nature09612 NIHMS688608
          10.1038/nature09612
          4431554
          21068831
          523c1cff-923a-461c-876b-f0bf39a383c2
          History

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