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      Electrochemical Sensors Based on Carbon Nanotubes

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          Abstract

          This review focuses on recent contributions in the development of the electrochemical sensors based on carbon nanotubes (CNTs). CNTs have unique mechanical and electronic properties, combined with chemical stability, and behave electrically as a metal or semiconductor, depending on their structure. For sensing applications, CNTs have many advantages such as small size with larger surface area, excellent electron transfer promoting ability when used as electrodes modifier in electrochemical reactions, and easy protein immobilization with retention of its activity for potential biosensors. CNTs play an important role in the performance of electrochemical biosensors, immunosensors, and DNA biosensors. Various methods have been developed for the design of sensors using CNTs in recent years. Herein we summarize the applications of CNTs in the construction of electrochemical sensors and biosensors along with other nanomaterials and conducting polymers.

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          Most cited references225

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          Electrochemical glucose sensors and their applications in diabetes management.

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            Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers.

            We describe herein the combination of electrochemical immunosensors using single-wall carbon nanotube (SWNT) forest platforms with multi-label secondary antibody-nanotube bioconjugates for highly sensitive detection of a cancer biomarker in serum and tissue lysates. Greatly amplified sensitivity was attained by using bioconjugates featuring horseradish peroxidase (HRP) labels and secondary antibodies (Ab(2)) linked to carbon nanotubes (CNT) at high HRP/Ab(2) ratio. This approach provided a detection limit of 4 pg mL(-)(1) (100 amol mL(-)(1)), for prostate specific antigen (PSA) in 10 microL of undiluted calf serum, a mass detection limit of 40 fg. Accurate detection of PSA in human serum samples was demonstrated by comparison to standard ELISA assays. PSA was quantitatively measured in prostate tissue samples for which PSA could not be differentiated by the gold standard immunohistochemical staining method. These easily fabricated SWNT immunosensors show excellent promise for clinical screening of cancer biomarkers and point-of-care diagnostics.
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              Nanotechnology: carbon nanotubes with DNA recognition.

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                Author and article information

                Journal
                Sensors (Basel)
                Sensors (Basel)
                Sensors (Basel, Switzerland)
                Molecular Diversity Preservation International (MDPI)
                1424-8220
                2009
                30 March 2009
                : 9
                : 4
                : 2289-2319
                Affiliations
                [1 ] Department of Advanced Technology Fusion, Konkuk University, Seoul 143-701, Korea
                [2 ] Department of Applied Chemistry, Konkuk University, Chungju 380-701, Korea
                Author notes
                [* ]Authors to whom correspondence should be addressed; E-Mails: jjlee@ 123456kku.ac.kr (J.J.L.); marahman@ 123456kku.ac.kr (M.A.R.); Tel.: +82-43-840-3580, +82-43-840-3568; Fax: +82-43-851-4169
                Article
                sensors-09-02289
                10.3390/s90402289
                3348810
                22574013
                524259ec-4928-4d22-9ec6-a108e03daa4b
                © 2009 by the authors; licensee MDPI, Basel, Switzerland

                This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/).

                History
                : 8 January 2009
                : 17 March 2009
                : 30 March 2009
                Categories
                Review

                Biomedical engineering
                electrochemical sensors,carbon nanotubes,immunosensors,modified electrodes,biosensors,dna sensors

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