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      Adult Fanconi Syndrome, Amyloidosis and Marked x-Light Chain Proteinuria

      , , , ,

      Nephron

      S. Karger AG

      Fanconi syndrome, Amyloidosis, Light chain proteinuria

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          Abstract

          A 57-year-old Negro female patient is described with adult Fanconi syndrome, and marked x-light chain proteinuria over a 10-year period, without evidence of multiple myeloma. At necropsy, an unusual nodular form of amyloidosis was found. An antiserum to the x-chain was produced with a unique affinity for the glomerular amyloid of another patient with IgG-x myeloma. The urinary x-chain from both patients had an idiotypic antigenic site. The implications of these findings in relation to the pathogenesis of amyloid is discussed.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1973
          1973
          27 November 2008
          : 10
          : 1
          : 1-24
          Affiliations
          Renal Division, Department of Medicine and the Department of Pathology, Michael Reese Hospital, and the University of Chicago, Pritzker School of Medicine, Chicago, Ill
          Article
          180174 Nephron 1973;10:1–24
          10.1159/000180174
          4571924
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 24
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

          Fanconi syndrome, Amyloidosis, Light chain proteinuria

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