Adult Fanconi Syndrome, Amyloidosis and Marked x-Light Chain Proteinuria

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Abstract

A 57-year-old Negro female patient is described with adult Fanconi syndrome, and marked x-light chain proteinuria over a 10-year period, without evidence of multiple myeloma. At necropsy, an unusual nodular form of amyloidosis was found. An antiserum to the x-chain was produced with a unique affinity for the glomerular amyloid of another patient with IgG-x myeloma. The urinary x-chain from both patients had an idiotypic antigenic site. The implications of these findings in relation to the pathogenesis of amyloid is discussed.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1973

Publication date (Print): 1973

Publication date (Electronic): 27 November 2008

Volume: 10

Issue: 1

Pages: 1-24

Affiliations

Renal Division, Department of Medicine and the Department of Pathology, Michael Reese Hospital, and the University of Chicago, Pritzker School of Medicine, Chicago, Ill

Article

Publisher ID: 180174 Other ID: Nephron 1973;10:1–24

DOI: 10.1159/000180174

PubMed ID: 4571924

SO-VID: 52430d36-0c77-4a52-b83b-4074d08533bd

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Adult Fanconi Syndrome, Amyloidosis and Marked x-Light Chain Proteinuria

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Karger: Nephrology

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