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      Cross-Talk between Two Organs: How the Kidney Responds to Disruption of Acid-Base Balance by the Lung

      ,

      Nephron Physiology

      S. Karger AG

      Respiratory acidosis, Hypercapnia, Respiratory alkalosis, Hypocapnia

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          Abstract

          Hypoventilation increases PaCO<sub>2</sub> (hypercapnia) and initiates the acid-base disorder known as respiratory acidosis. Hyperventilation decreases PaCO<sub>2</sub> (hypocapnia) and initiates the acid-base disorder known as respiratory alkalosis. The impact on acidity of these primary changes in PaCO<sub>2</sub> is ameliorated by secondary, directional changes in plasma bicarbonate concentration that occur in two stages. Acutely, modest changes in plasma bicarbonate originate from titration of the body’s nonbicarbonate buffers. In chronic hypercapnia and hypocapnia, larger changes in plasma bicarbonate occur that reflect adjustments in renal acidification mechanisms. As a result, the amelioration of systemic acidity is more pronounced in the chronic forms of the respiratory acid-base disorders.

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          Author and article information

          Journal
          NEP
          Nephron Physiol
          10.1159/issn.1660-2137
          Nephron Physiology
          S. Karger AG
          1660-2137
          2003
          March 2003
          31 March 2003
          : 93
          : 3
          : p61-p66
          Affiliations
          Department of Medicine, Tufts University School of Medicine, and the Division of Nephrology and the Tupper Research Institute, Tufts-New England Medical Center, Boston, Mass., and Department of Medicine, Baylor College of Medicine, and Renal Section, Veterans Affairs Medical Center, Houston, Tex., USA
          Article
          69557 Nephron Physiol 2003;93:p61–p66
          10.1159/000069557
          12660492
          © 2003 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 2, References: 35, Pages: 1
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/69557
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