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      Cross-Talk between Two Organs: How the Kidney Responds to Disruption of Acid-Base Balance by the Lung


      Nephron Physiology

      S. Karger AG

      Respiratory acidosis, Hypercapnia, Respiratory alkalosis, Hypocapnia

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          Hypoventilation increases PaCO<sub>2</sub> (hypercapnia) and initiates the acid-base disorder known as respiratory acidosis. Hyperventilation decreases PaCO<sub>2</sub> (hypocapnia) and initiates the acid-base disorder known as respiratory alkalosis. The impact on acidity of these primary changes in PaCO<sub>2</sub> is ameliorated by secondary, directional changes in plasma bicarbonate concentration that occur in two stages. Acutely, modest changes in plasma bicarbonate originate from titration of the body’s nonbicarbonate buffers. In chronic hypercapnia and hypocapnia, larger changes in plasma bicarbonate occur that reflect adjustments in renal acidification mechanisms. As a result, the amelioration of systemic acidity is more pronounced in the chronic forms of the respiratory acid-base disorders.

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          Author and article information

          Nephron Physiol
          Nephron Physiology
          S. Karger AG
          March 2003
          31 March 2003
          : 93
          : 3
          : p61-p66
          Department of Medicine, Tufts University School of Medicine, and the Division of Nephrology and the Tupper Research Institute, Tufts-New England Medical Center, Boston, Mass., and Department of Medicine, Baylor College of Medicine, and Renal Section, Veterans Affairs Medical Center, Houston, Tex., USA
          69557 Nephron Physiol 2003;93:p61–p66
          © 2003 S. Karger AG, Basel

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          Figures: 2, References: 35, Pages: 1
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