We studied the effects of furosemide on pulmonary mechanics in 10 infants with bronchopulmonary
dysplasia aged 41 +/- 1 (SE) weeks post-conception, gestational age at birth 30 +/-
1 wk, birth weight 1370 +/- 200 gm. Thoracic gas volume, airways resistance, and specific
airway conductance were measured in an infant body pressure plethysmograph during
quiet breathing. Dynamic pulmonary compliance was measured using an esophageal balloon.
Infants with BPD had greater Raw, lower SGaw, and lower Cdyn than did 16 normal control
infants. Within one hour after administration of furosemide 1 mg/kg IV to infants
with BPD, Raw fell 36 +/- 13%, SGaw increased 84 +/- 22%, and Cdyn increased 54 +/-
13%; TGV did not change. Diuretic treatment of BPD in infants is associated with rapid,
short-term improvement in Raw and Cdyn.