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      Real-time tracking of self-reported symptoms to predict potential COVID-19

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          Abstract

          <p class="first" id="P3">A total of 2,618,862 participants reported their potential symptoms of COVID-19 on a smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2 test, the proportion of participants who reported loss of smell and taste was higher in those with a positive test result (4,668 of 7,178 individuals; 65.03%) than in those with a negative test result (2,436 of 11,223 participants; 21.71%) (odds ratio = 6.74; 95% confidence interval = 6.31–7.21). A model combining symptoms to predict probable infection was applied to the data from all app users who reported symptoms (805,753) and predicted that 140,312 (17.42%) participants are likely to have COVID-19. </p>

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          Most cited references8

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          SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

          We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
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            Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection

            This study reports on the prevalence, intensity, and timing of an altered sense of smell or taste in patients with SARS-CoV-2 infections.
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              • Record: found
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              Sudden and Complete Olfactory Loss Function as a Possible Symptom of COVID-19

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                Author and article information

                Journal
                Nature Medicine
                Nat Med
                Springer Science and Business Media LLC
                1078-8956
                1546-170X
                May 11 2020
                Article
                10.1038/s41591-020-0916-2
                7751267
                32393804
                525c5a11-5e81-4389-91ba-09e5c3f9a05a
                © 2020

                Free to read

                http://www.springer.com/tdm

                http://www.springer.com/tdm

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