Surrogate endpoints in liver surgery related trials: a systematic review of the literature.

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Abstract

Although the safety of liver surgery has improved enormously, hepatic surgery continues to face challenging complications. Therefore, improvements supported by evidence-based guidelines are still required. The conduct of randomized controlled trials in liver surgery using dichotomous outcomes requires a large sample size. The use of surrogate endpoints (SEPs) reduces sample size but SEPs should be validated before use.

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Journal

Journal ID (iso-abbrev): HPB (Oxford)

Title: HPB : the official journal of the International Hepato Pancreato Biliary Association

ISSN (Electronic): 1477-2574

ISSN (Print): 1365-182X

Publication date (Electronic): May 2013

Volume: 15

Issue: 5

Affiliations

[1 ] Department of Surgery, Maastricht University Medical Centre, and NUTRIM School of Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, the Netherlands.

Article

Publisher Item ID: S1365-182X(15)31403-9

DOI: 10.1111/j.1477-2574.2012.00590.x

PMC ID: 3633033

PubMed ID: 23323939

SO-VID: 5274c4b2-00a1-4b9d-a141-cab1e9c1a574

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