91
views
0
recommends
+1 Recommend
0 collections
    1
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Association of Frequency of Organic Food Consumption With Cancer Risk : Findings From the NutriNet-Santé Prospective Cohort Study

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          <div class="section"> <a class="named-anchor" id="ab-ioi180070-1"> <!-- named anchor --> </a> <h5 class="section-title" id="d1999865e406">Question</h5> <p id="d1999865e408">What is the association between an organic food–based diet (ie, a diet less likely to contain pesticide residues) and cancer risk? </p> </div><div class="section"> <a class="named-anchor" id="ab-ioi180070-2"> <!-- named anchor --> </a> <h5 class="section-title" id="d1999865e411">Findings</h5> <p id="d1999865e413">In a population-based cohort study of 68 946 French adults, a significant reduction in the risk of cancer was observed among high consumers of organic food. </p> </div><div class="section"> <a class="named-anchor" id="ab-ioi180070-3"> <!-- named anchor --> </a> <h5 class="section-title" id="d1999865e416">Meaning</h5> <p id="d1999865e418">A higher frequency of organic food consumption was associated with a reduced risk of cancer; if the findings are confirmed, research investigating the underlying factors involved with this association is needed to implement adapted and targeted public health measures for cancer prevention. </p> </div><div class="section"> <a class="named-anchor" id="ab-ioi180070-4"> <!-- named anchor --> </a> <h5 class="section-title" id="d1999865e422">Importance</h5> <p id="d1999865e424">Although organic foods are less likely to contain pesticide residues than conventional foods, few studies have examined the association of organic food consumption with cancer risk. </p> </div><div class="section"> <a class="named-anchor" id="ab-ioi180070-5"> <!-- named anchor --> </a> <h5 class="section-title" id="d1999865e427">Objective</h5> <p id="d1999865e429">To prospectively investigate the association between organic food consumption and the risk of cancer in a large cohort of French adults. </p> </div><div class="section"> <a class="named-anchor" id="ab-ioi180070-6"> <!-- named anchor --> </a> <h5 class="section-title" id="d1999865e432">Design, Setting, and Participants</h5> <p id="d1999865e434">In this population-based prospective cohort study among French adult volunteers, data were included from participants with available information on organic food consumption frequency and dietary intake. For 16 products, participants reported their consumption frequency of labeled organic foods (never, occasionally, or most of the time). An organic food score was then computed (range, 0-32 points). The follow-up dates were May 10, 2009, to November 30, 2016. </p> </div><div class="section"> <a class="named-anchor" id="ab-ioi180070-7"> <!-- named anchor --> </a> <h5 class="section-title" id="d1999865e437">Main Outcomes and Measures</h5> <p id="d1999865e439">This study estimated the risk of cancer in association with the organic food score (modeled as quartiles) using Cox proportional hazards regression models adjusted for potential cancer risk factors. </p> </div><div class="section"> <a class="named-anchor" id="ab-ioi180070-8"> <!-- named anchor --> </a> <h5 class="section-title" id="d1999865e442">Results</h5> <p id="d1999865e444">Among 68 946 participants (78.0% female; mean [SD] age at baseline, 44.2 [14.5] years), 1340 first incident cancer cases were identified during follow-up, with the most prevalent being 459 breast cancers, 180 prostate cancers, 135 skin cancers, 99 colorectal cancers, 47 non-Hodgkin lymphomas, and 15 other lymphomas. High organic food scores were inversely associated with the overall risk of cancer (hazard ratio for quartile 4 vs quartile 1, 0.75; 95% CI, 0.63-0.88; <i>P</i> for trend = .001; absolute risk reduction, 0.6%; hazard ratio for a 5-point increase, 0.92; 95% CI, 0.88-0.96). </p> </div><div class="section"> <a class="named-anchor" id="ab-ioi180070-9"> <!-- named anchor --> </a> <h5 class="section-title" id="d1999865e450">Conclusions and Relevance</h5> <p id="d1999865e452">A higher frequency of organic food consumption was associated with a reduced risk of cancer. If these findings are confirmed, further research is necessary to determine the underlying factors involved in this association. </p> </div><p class="first" id="d1999865e455">This population-based cohort study investigates the association between organic food consumption and the risk of cancer in a large cohort of French adults. </p>

          Related collections

          Most cited references28

          • Record: found
          • Abstract: found
          • Article: not found

          Pesticides and human chronic diseases: evidences, mechanisms, and perspectives.

          Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders. There is also circumstantial evidence on the association of exposure to pesticides with some other chronic diseases like respiratory problems, particularly asthma and chronic obstructive pulmonary disease (COPD), cardiovascular disease such as atherosclerosis and coronary artery disease, chronic nephropathies, autoimmune diseases like systemic lupus erythematous and rheumatoid arthritis, chronic fatigue syndrome, and aging. The common feature of chronic disorders is a disturbance in cellular homeostasis, which can be induced via pesticides' primary action like perturbation of ion channels, enzymes, receptors, etc., or can as well be mediated via pathways other than the main mechanism. In this review, we present the highlighted evidence on the association of pesticide's exposure with the incidence of chronic diseases and introduce genetic damages, epigenetic modifications, endocrine disruption, mitochondrial dysfunction, oxidative stress, endoplasmic reticulum stress and unfolded protein response (UPR), impairment of ubiquitin proteasome system, and defective autophagy as the effective mechanisms of action. Copyright © 2013 Elsevier Inc. All rights reserved.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate.

              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              The Nutrinet-Santé Study: a web-based prospective study on the relationship between nutrition and health and determinants of dietary patterns and nutritional status

              Background Nutrition-related chronic diseases such as cardiovascular diseases and cancer are of multiple origin, and may be due to genetic, biologic, behavioural and environmental factors. In order to detangle the specific role of nutritional factors, very large population sample cohort studies comprising precisely measured dietary intake and all necessary information for accurately assessing potential confounding factors are needed. Widespread use of internet is an opportunity to gradually collect huge amounts of data from a large sample of volunteers that can be automatically verified and processed. The objectives of the NutriNet-Santé study are: 1) to investigate the relationship between nutrition (nutrients, foods, dietary patterns, physical activity), mortality and health outcomes; and 2) to examine the determinants of dietary patterns and nutritional status (sociological, economic, cultural, biological, cognitive, perceptions, preferences, etc.), using a web-based approach. Methods/design Our web-based prospective cohort study is being conducted for a scheduled follow-up of 10 years. Using a dedicated web site, recruitment will be carried out for 5 years so as to register 500 000 volunteers aged ≥ 18 years among whom 60% are expected to be included (having complete baseline data) and followed-up for at least 5 years for 240 000 participants. Questionnaires administered via internet at baseline and each year thereafter will assess socio-demographic and lifestyle characteristics, anthropometry, health status, physical activity and diet. Surveillance of health events will be implemented via questionnaires on hospitalisation and use of medication, and linkage with a national database on vital statistics. Biochemical samples and clinical examination will be collected in a subsample of volunteers. Discussion Self-administered data collection using internet as a complement to collection of biological data will enable identifying nutrition-related risks and protective factors, thereby more clearly elucidating determinants of nutritional status and their interactions. These are necessary steps for further refining nutritional recommendations aimed at improving the health status of populations.
                Bookmark

                Author and article information

                Journal
                JAMA Internal Medicine
                JAMA Intern Med
                American Medical Association (AMA)
                2168-6106
                December 01 2018
                December 01 2018
                : 178
                : 12
                : 1597
                Affiliations
                [1 ]Centre de Recherche Epidémiologie et Statistique Sorbonne Paris Cité, Institut National de la Santé et de la Recherche Médicale (INSERM) U1153, Institut National de la Recherche Agronomique (INRA) U1125, Conservatoire National des Arts et Métiers, Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle, Bobigny, France
                [2 ]Département de Dermatologie, Hôpital St André, Bordeaux, France
                [3 ]Département de Santé Publique, Hôpital Avicenne, Bobigny, France
                [4 ]Centre de Recherche en Cardiovasculaire et Nutrition, Aix Marseille Université, INSERM, INRA, Marseille, France
                Article
                10.1001/jamainternmed.2018.4357
                6583612
                30422212
                527c8582-09fb-4ad5-b067-75098edc704f
                © 2018
                History

                Comments

                Comment on this article