There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Pharmacokinetic parameters of oxfendazole (OFZ) were determined in five sheep submitted
to two different feeding regimens: a poor/dry diet based on wheat straw ad libitum,
and a rich/green diet based on fresh grass grazed on pasture. Animals were acclimatised
to each diet before they were administered OFZ orally at a dose of 5 mg kg-1 body
weight. Blood samples were taken serially between 10 min and 168 h post-administration.
Plasma concentrations of OFZ and its metabolites (fenbendazole (FBZ) and fenbendazole
sulphone) were quantified using an HPLC technique. Rates of absorption of OFZ and
of formation of FBZ and fenbendazole sulphone were slower with the poor/dry diet;
however, the area under FBZ plasma concentration vs time curve was higher when sheep
were offered the low quality diet, suggesting a shift of OFZ metabolism towards FBZ
formation.