Allostatic load (AL) is related to stress. Adverse childhood experiences (ACEs), as a common stress in childhood, can make a serious and lasting impact on it. Allostatic load can reflect the wear and tear of an individual’s physiological system. This article mainly reviews the functional changes of several systems of AL who have experienced ACEs, including neuroendocrine, metabolism, immune, and cardiovascular systems, as well as the different effects of the occurrence time and subtypes of ACES on AL, providing some theoretical basis for the development of early intervention plans in the future and reducing the occurrence and development of deleterious outcomes.
【摘要】非稳态负荷 (allostatic load, AL) 主要与压力应激有关, 而童年期逆境 (adverse childhood experiences, ACEs) 作为 童年时期常见的应激源能对其产生严重且持久的影响。AL能够反映个体多个生理系统的综合磨损情况。该文主要综述 了经历ACEs的个体对其AL各系统的影响和作用机制, 以及ACEs的发生时间、亚型对AL的不同影响, 为未来制定早期 干预计划, 减少不良结局的发生发展提供一定的理论基础。