First external quality assurance program of the Italian HLA-B*57:01 Network assessing the performance of clinical virology laboratories in HLA-B*57:01 testing.

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Abstract

Since the HLA-B*57:01 allele is strongly associated with abacavir hypersensitivity reaction, testing for the presence of HLA-B*57:01 is mandatory before administration of abacavir. While HLA-B*57:01 testing is usually provided by pharmacogenetics, genetics or blood transfusion services, clinical virology laboratories can be an optimal opportunity for HLA-B*57:01 testing since they receive blood samples for routine HIV monitoring and have the expertise for convenient and less expensive PCR-based point mutation assays.

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Journal

Journal ID (iso-abbrev): J. Clin. Virol.

Title: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

Publisher: Elsevier BV

ISSN (Electronic): 1873-5967

ISSN (Print): 1386-6532

Publication date (Electronic): May 2016

Volume: 78

Affiliations

[1 ] Department of Medical Biotechnology, University of Siena, viale Mario Bracci n.16, 53100 Siena, Italy. Electronic address: genny.meini@gmail.com.

[2 ] Institute of Pharmacology, Catholic University Medical School, Rome, Italy. Electronic address: cinzia.dellorusso@rm.unicatt.it.

[3 ] Laboratory of Microbiology and Virology, Amedeo di Savoia Hospital, c.so Svizzera 164, 10149 Torino, Italy. Electronic address: tiziano.allice@aslto2.piemonte.it.

[4 ] Hygiene Unit, IRCCS AOU San Martino-IST, Genoa, Italy. Electronic address: renata.barresi@hsanmartino.it.

[5 ] I.N.M.I. Lazzaro Spallanzani, Rome, Italy. Electronic address: roberta.darrigo@inmi.it.

[6 ] Department of Molecular Medicine, Sapienza University of Rome, Italy. Electronic address: francesca.falasca@uniroma1.it.

[7 ] Ospedali Riuniti di Foggia, viale Luigi Pinto, 71100 Foggia, Italy. Electronic address: marlip@tiscalinet.it.

[8 ] IRCCS S. Matteo Hospital, Pavia, Italy. Electronic address: S.Paolucci@smatteo.pv.it.

[9 ] Microbiology, Immunology and Virology Unit, IRCCS CRO Aviano National Cancer Institute, via Gallini n.2, Aviano, 33081 PN, Italy. Electronic address: szanussi@cro.it.

[10 ] Ospedali Riuniti di Foggia, viale Luigi Pinto, 71100 Foggia, Italy. Electronic address: rantonetti@ospedaliriunitifoggia.it.

[11 ] IRCCS S. Matteo Hospital, Pavia, Italy. Electronic address: f.baldanti@smatteo.pv.it.

[12 ] Microbiology, Immunology and Virology Unit, IRCCS CRO Aviano National Cancer Institute, via Gallini n.2, Aviano, 33081 PN, Italy. Electronic address: gbasaglia@cro.it.

[13 ] Hygiene Unit, IRCCS AOU San Martino-IST, Genoa, Italy. Electronic address: bianca.bruzzone@hsanmartino.it.

[14 ] Ospedale Civile Spirito Santo di Pescara, Pescara, Italy. Electronic address: e.polilli@libero.it.

[15 ] Laboratory of Microbiology and Virology, Amedeo di Savoia Hospital, c.so Svizzera 164, 10149 Torino, Italy. Electronic address: valeria.ghisetti@unito.it.

[16 ] I.N.M.I. Lazzaro Spallanzani, Rome, Italy. Electronic address: leopoldo.pucillo@inmi.it.

[17 ] Department of Molecular Medicine, Sapienza University of Rome, Italy. Electronic address: ombretta.turriziani@uniroma1.it.

[18 ] ViiV Healthcare s.r.l, via Fleming 2, 37135 Verona, Italy. Electronic address: antonella.a.pirazzoli@viivhealthcare.com.

[19 ] Institute of Pharmacology, Catholic University Medical School, Rome, Italy. Electronic address: pnavarra@rm.unicatt.it.

[20 ] Department of Medical Biotechnology, University of Siena, viale Mario Bracci n.16, 53100 Siena, Italy. Electronic address: maurizio.zazzi@gmail.com.

Article

Publisher Item ID: S1386-6532(16)30012-9

DOI: 10.1016/j.jcv.2016.02.020

PubMed ID: 26946153

SO-VID: 52ad7c6c-978f-4ce2-8f32-ea3ddab1223a

History

Keywords: Abacavir hypersensitivity reaction,External quality assurance,HIV,HLA-B*57:01 testing

Data availability:

Keywords: Abacavir hypersensitivity reaction, External quality assurance, HIV, HLA-B*57:01 testing

First external quality assurance program of the Italian HLA-B57:01 Network assessing the performance of clinical virology laboratories in HLA-B57:01 testing.

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