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      Unusual clinical presentations of giant prolactinomas.

      1 ,
      Pituitary

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          Abstract

          Giant prolactinomas are rare pituitary tumors which have scarcely been reported in the literature. We describe three men with unusual presenting features of prolactin-secreting giant pituitary adenomas: prolonged and increasingly disturbing intolerance to light and noise; strange behavior and mood disturbances; and rhinorrhea followed by a finding of cerebrospinal fluid leakage. Treatment with dopamine agonist alleviated all symptoms, with concomitant suppression of plasma prolactin levels and a significant reduction in tumor mass. These cases emphasize the importance of considering unusual symptoms in the differential diagnosis of giant prolactinomas and the effectiveness of medical treatment.

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          Author and article information

          Journal
          Pituitary
          Pituitary
          1573-7403
          1386-341X
          Dec 2011
          : 14
          : 4
          Affiliations
          [1 ] Institute of Endocrinology & Metabolism, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa, Israel.
          Article
          10.1007/s11102-008-0160-0
          19104942
          52b8d884-68a0-4ee6-a033-0945029d6824
          History

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