Gastric Electrical Stimulation in Intractable Symptomatic Gastroparesis

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background: The treatment of gastroparesis remains unsatisfactory despite prokinetic and anti-emetic drugs. Gastric electrical stimulation has been proposed as a therapeutic option. We have assessed the effect of gastric electrical stimulation on symptoms, medical treatment, body weight and gastric emptying in patients with intractable symptomatic gastroparesis in a non-placebo-controlled study. Methods: In this multicenter study, 38 highly symptomatic patients with drug-refractory gastroparesis were enrolled. Patients first received temporary electrical stimulation using percutaneous electrodes. The 33 responders to temporary stimulation then underwent surgical implantation of a permanent stimulator. Severity of vomiting and nausea was assessed before and after stimulation. Patients were reassessed 3, 6, and 12 months after permanent implantation. Results: With stimulation, 35/38 patients (97%) experienced >80% reduction in vomiting and nausea. This effect persisted throughout the observation period (2.9–15.6 months, 341 patient-months). Gastric emptying did not initially change, but improved in most patients at 12 months. At 1 year, the average weight gain was 5.5% and 9/14 patients initially receiving enteral or parenteral nutrition were able to discontinue it. Conclusion: Electrical stimulation of the stomach has an immediate and potent anti-emetic effect. It offers a safe and effective alternative for patients with intractable symptomatic gastroparesis.

Related collections

Author and article information

Journal

Journal ID (publisher-id): DIG

Journal ID (nlm-ta): Digestion

Journal ID (doi): 10.1159/issn.0012-2823

Title: Digestion

Publisher: S. Karger AG

ISSN (Print): 0012-2823

ISSN (Electronic): 1421-9867

Publication date Subscription-year: 2002

Publication date (Print): 2002

Publication date (Electronic): 24 February 2003

Volume: 66

Issue: 4

Pages: 204-212

Affiliations

^aUniversity of Mississippi Medical Center, Jackson, Miss., USA; ^bUniversity Hospital Gasthuisberg, Leuven, Belgium; ^cGötheborgs Universitet, Göteborg, Sweden; ^dMcMaster University Medical Centre, Hamilton, Ontario, Canada; ^eWestfälische Wilhelms-Universität, Münster, Germany; ^fCentre Hospitalier Universitaire de Nantes, Nantes, France; ^gUniversity of Memphis, Department of Electrical Engineering, Memphis, Tenn., USA; ^hBakkenResearch Center, Maastricht, The Netherlands

Article

Publisher ID: 68359 Other ID: Digestion 2002;66:204–212

DOI: 10.1159/000068359

PubMed ID: 12592096

SO-VID: 52baff72-5289-41b3-bdac-a6c541502fd1

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 07 May 2002

Date accepted : 22 August 2002

Page count

Figures: 1, Tables: 5, References: 31, Pages: 9

Comments

Comment on this article

scite_

Cited by 31

See all cited by

- Version 1

Call for Papers: Artificial Intelligence in Gastroenterology

Submit here before May 31, 2024