1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Enzymatically Triggered Rupture of Polymersomes

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Polymersomes are robust vesicles made from amphiphilic block co-polymers. Large populations of uniform giant polymersomes with defined, entrapped species can be made by templating of double-emulsions using microfluidics. In the present study, a series of two enzymatic reactions, one inside and the other outside of a polymersome, were designed to give rise to induced rupture of polymersomes. We measured how the kinetics of rupture were affected by altering enzyme concentration. These results suggest that protocells with entrapped enzymes can be engineered to secrete entrapped materials on cue.

          Related collections

          Author and article information

          Contributors
          Journal
          101295070
          34116
          Soft Matter
          Soft Matter
          Soft matter
          1744-683X
          1744-6848
          12 November 2016
          28 January 2016
          09 December 2016
          : 12
          : 4
          : 1014-1020
          Affiliations
          [a ]Department of Chemical and Biomolecular Engineering, The University of Pennsylvania, Philadelphia PA
          [b ]Department of Chemical Engineering, Rowan Univeersity, Glassboro, NJ
          [c ]Harriton High School, Rosemont PA
          [d ]Department of Bioengineering, The University of Pennsylvania, Philadelphia PA
          Article
          PMC5148629 PMC5148629 5148629 nihpa829332
          10.1039/c5sm01881a
          5148629
          26616557
          52d35692-a9d4-476d-a0a4-dfb87a97149e
          History
          Categories
          Article

          Comments

          Comment on this article