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      Sensitivity and Safety of Electromagnetic Navigation Bronchoscopy for Lung Cancer Diagnosis

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          Abstract

          <p class="first" id="d120962e158">Bronchoscopy is a useful tool for the diagnosis of lesions near central airways; however, the diagnostic accuracy of these procedures for peripheral pulmonary lesions (PPLs) is a matter of ongoing debate. In this setting, electromagnetic navigation bronchoscopy (ENB) is a technique used to navigate and obtain samples from these lesions. This systematic review and meta-analysis aims to explore the sensitivity of ENB in patients with PPLs suspected of lung cancer. </p>

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          Measuring inconsistency in meta-analyses.

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            QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies.

            In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.
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              Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies

              Systematic reviews of diagnostic test accuracy synthesize data from primary diagnostic studies that have evaluated the accuracy of 1 or more index tests against a reference standard, provide estimates of test performance, allow comparisons of the accuracy of different tests, and facilitate the identification of sources of variability in test accuracy.
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                Author and article information

                Journal
                Chest
                Chest
                Elsevier BV
                00123692
                October 2020
                October 2020
                : 158
                : 4
                : 1753-1769
                Article
                10.1016/j.chest.2020.05.534
                32450240
                52e1ac80-a343-435c-a61a-c197357bc2eb
                © 2020

                https://www.elsevier.com/tdm/userlicense/1.0/

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