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      Sphenoid Inverted Nasal Papilloma Presenting as Chronic Headaches in a 21-Year-Old Patient: A Case Report and Literature Review

      case-report
      1 , 2 , 1 , 1 , , 3
      ,
      Cureus
      Cureus
      recurrence, case report, inverted papilloma, schneiderian papilloma, sphenoid sinus

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          Abstract

          An inverted papilloma is a rare, benign tumor that affects the nasal cavity and paranasal sinuses. The maxillary and ethmoid sinuses are the most commonly affected, while the involvement of the sphenoid sinus is rare and may be associated with malignancy. We describe the case of a 21-year-old female who presented with recurring headaches along with dizziness, difficulty concentrating, mild hypoacusis, and occasional nasal congestion. A CT of the sinuses showed a soft tissue lesion in the sphenoidal sinus with extension into the posterior ethmoidal cells. After the biopsy, the patient was ultimately diagnosed with sphenoid inverted nasal papilloma. 

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          Most cited references19

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          Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review

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            Inverted papilloma: a report of 112 cases.

            Inverted papilloma is a benign sinonasal tumor which is locally aggressive and has a significant malignant potential. This report updates the experience of the two senior authors, who have treated 112 patients with inverted papilloma at the Mount Sinai Medical Center over a 20-year period. As clinical examination often underestimates tumor extent, preoperative radiographic assessment is of paramount importance in guiding selection of surgical therapy. Complete en bloc excision via lateral rhinotomy and medial maxillectomy was the method of treatment in the majority of patients (84%). In selected patients with limited disease, or in patients who refused en bloc excision, conservative therapy employing intranasal or transantral ethmoidectomy was performed. The recurrence rates for the two groups were 14% and 20%, respectively. Recurrent disease developed throughout the paranasal sinuses, with the maxillary antrum and ethmoid labyrinth constituting the major sites. In two patients presenting with anterior skull base erosion, craniofacial resection was undertaken to eradicate disease. The latter cases underscore the aggressive nature of the tumor if left untreated. The overall rate of squamous carcinoma in this series was 5%. Given the predilection for local recurrence, multicentricity, and the possibility of malignancy, the authors continue to recommend lateral rhinotomy and medial maxillectomy as the standard therapy for the majority of cases. Management principles as well as a review of the literature are discussed.
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              Does human papilloma virus play a role in sinonasal inverted papilloma?

              Inverted papillomas are a benign sinonasal tumor with a propensity for recurrence and malignant transformation. Although many investigations have been made into the nature of this disease, its etiology and causes for malignant transformation have yet to be fully elucidated. It is the authors' objective to present a review on management of the disease and evaluate the present relationship between human papilloma virus (HPV) and inverted papilloma.
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                Author and article information

                Journal
                Cureus
                Cureus
                2168-8184
                Cureus
                Cureus (Palo Alto (CA) )
                2168-8184
                24 July 2024
                July 2024
                : 16
                : 7
                : e65262
                Affiliations
                [1 ] School of Medicine, Pontificia Universidad Católica Madre y Maestra, Santiago, DOM
                [2 ] School of Medicine, Universidad Iberoamericana (UNIBE), Santo Domingo, DOM
                [3 ] Department of Radiology, Diagnostica Social -Patronato Benéfico Oriental (PBO), La Romana, DOM
                Author notes
                Article
                10.7759/cureus.65262
                11342577
                52f9245e-ab5c-4909-9290-0ff042a04af4
                Copyright © 2024, Gonzalez et al.

                This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 24 July 2024
                Categories
                Anatomy
                Otolaryngology
                Radiology

                recurrence,case report,inverted papilloma,schneiderian papilloma,sphenoid sinus

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