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      Treatment history and antimicrobial susceptibility results for Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni isolates from bovine respiratory disease cases submitted to the Iowa State University Veterinary Diagnostic Laboratory from 2013 to 2015

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          Abstract

          Bovine respiratory disease is the most costly disease facing the cattle industry. Increasing resistance to antimicrobial treatment has been presented as a significant contributing factor, often through summarized susceptibility testing data. We assessed the relationship between previous antimicrobial treatment and antimicrobial susceptibility results from isolates of Mannheimia haemolytica , Pasteurella multocida, and Histophilus somni cultured from bovine respiratory cases submitted to the Iowa State University Veterinary Diagnostic Laboratory from 2013 to 2015. Antimicrobial susceptibility data from 1,251 bacterial isolates were included for analysis. More bacterial isolates from cattle that received antimicrobial treatment showed resistance compared to isolates from untreated cattle, and the percentage of resistant isolates increased as the number of antimicrobial treatments increased. Resistance to enrofloxacin, spectinomycin, tilmicosin, and tulathromycin was present in >75% of M. haemolytica isolates from cattle that had received 3 or more antimicrobial treatments; resistance to each of those 4 antimicrobials was present in ≤10% of M. haemolytica isolates from untreated cattle. Similar but less dramatic trends were apparent for isolates of P. multocida and H. somni. The percentage of multi-drug resistant bacterial isolates also increased with the number of treatments. Results of our study suggest that previous antimicrobial treatment may have a profound effect on antimicrobial susceptibility testing. Summarized susceptibility results from diagnostic laboratories should not be used to make generalized statements regarding trends in antimicrobial resistance without providing context regarding antimicrobial treatment history.

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          Author and article information

          Journal
          J Vet Diagn Invest
          J. Vet. Diagn. Invest
          VDI
          spvdi
          Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
          SAGE Publications (Sage CA: Los Angeles, CA )
          1040-6387
          1943-4936
          15 October 2017
          January 2018
          : 30
          : 1
          : 99-104
          Affiliations
          [1-1040638717737589]Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA
          Author notes
          [*] [1 ]Drew R. Magstadt, Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 1800 Christensen Drive, Ames, IA 50011. magstadt@ 123456iastate.edu
          Article
          PMC6504160 PMC6504160 6504160 10.1177_1040638717737589
          10.1177/1040638717737589
          6504160
          29034785
          52f9aac9-9ecf-48cf-a680-17da5ec556e6
          © 2017 The Author(s)
          History
          Categories
          Full Scientific Reports

          Histophilus ,Antimicrobial resistance, Mannheimia , Pasteurella ,bovine respiratory disease,susceptibility testing

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