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      Interaction of Aging with in vitro Adrenocortical Responsiveness to ACTH and Cyclic AMP

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          Abstract

          In vitro adrenal accumulation of cyclic 3´5´-adenosine monophosphate (cyclic AMP) and release of corticosterone in response to adrenocorticotropic hormone (ACTH), cyclic AMP or theophylline was assessed in 60- and 340-day-old male rats. Adrenal tissue from mature animals secreted significantly smaller quantities of corticosterone in response to ACTH, theophylline or cyclic AMP. Additionally, mature tissue accumulated significantly less cyclic AMP after treatment with ACTH or a combination of ACTH and theophylline. The data suggest an age-related refractoriness of adrenal cortical tissue to ACTH which may in part be related to decreased availability of and/or sensitivity to cyclic AMP.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1979
          1979
          25 November 2008
          : 10
          : 2-3
          : 96-103
          Affiliations
          Physiology Laboratories, Departments of Zoology-Entomology and Animal Science, Agricultural Experiment Station, Auburn University, Auburn, Ala
          Article
          178993 Horm Res 1979;10:96–103
          10.1159/000178993
          220172
          © 1979 S. Karger AG, Basel

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          Pages: 8
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