0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Somatostatin in the Hippocampus Mediates Dexamethasone-Induced Suppression of Corticosterone Secretion in the Rat

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          We evaluated the effect of different manipulations of central somatostatin (SS) neurons on dexamethasone (Dex) induced suppression of the hypophyseal-pituitary axis. The Dex suppression test was performed in male rats by evaluating the reduction of plasma levels of corticosterone occurring 4 h after administration of Dex. Administration of cysteamine, a depletor of SS stores, or passive immunization by intracerebroventricular administration of a saturating dose of anti-SS γ-globulins completely suppressed the ability of Dex to reduce plasma corticosterone levels. Additionally, anti-SS γ-globulins, infused under stereotaxic control into two discrete areas of the hippocampus (CA3 and DG), completely blocked Dex-induced inhibition of corticosterone secretion. These data indicate that hippocampal SS neurons play a role in the negative feedback regulation of glucocorticoid secretion.

          Related collections

          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1991
          1991
          04 April 2008
          : 53
          : 4
          : 428-431
          Affiliations
          aDepartment of Pharmacology, Chemotherapy, and Toxicology, University of Milan; bDepartment of Pharmacobiology, University of Ban, Italy
          Article
          125752 Neuroendocrinology 1991;53:428–431
          10.1159/000125752
          1675439
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Rapid Communication

          Comments

          Comment on this article