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      Long-Term GH Therapy: Epidemiology and Auxologic Outcome

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          Abstract

          Objectives: Epidemiologic and auxologic characteristics of patients treated with GH during childhood and adolescence and entered in a national registry in Catalonia were studied between 1988 and 1997. At the end of 1997, prevalence was 53.2 treatments/100,000 inhabitants aged 0–14 years. Maximum annual incidence rates were observed in 1990 and 1991 (34.0–35.6 cases/100,000 inhabitants aged 0–14 years). Study Design: Analysis of treatments terminated in 1993 (n = 548) revealed, for the three principal reasons for cessation of treatment (‘near-final height’, ‘adequate height but further growth potential’, and ‘poor growth response’), that males began and ended treatment at older ages with a better auxologic situation in SDS than girls at the beginning and end of therapy in the first two subgroups, with a similar duration of therapy. Severe GH deficiency (GHD) [both multiple pituitary hormone deficiency (MPHD) and the most severe isolated GHD (IGHD-A)] was more frequent in the group ending treatment at ‘near-final height’, whereas cessation of therapy because of ‘poor growth response’ was more frequent in the group with ‘other causes of short stature’ and no demonstrable GHD by routine tests. In the near-final height group, after excluding Turner’s syndrome, MPHD and GHD cases secondary to brain tumors and GH deficiencies associated with malformative syndromes, positive linear correlations were observed between HSDS at the end of treatment and HSDS at the beginning, predicted adult height SDS (PAHSDS) and target height SDS (THSDS). Multiple regression analysis showed that in this group of patients, 41.4% of the variability in HSDS increment can be explained by the equation: HSDS increment = –0.33 + 0.29 THSDS – 0.68 HSDS at the beginning of treatment. Results: The outcome showed a reasonable use of GH, since good-response cases generally continued treatment until final height whereas therapy was suspended in doubtful cases.

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          Most cited references 2

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          • Article: not found

          Pitfalls in diagnosing impaired growth hormone (GH) secretion: retesting after replacement therapy of 63 patients defined as GH deficient

           E Cacciari (1992)
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            Diagnosis of Growth Hormone (GH) Deficiency and the Use of GH in Children with Growth Disorders

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              Author and article information

              Journal
              HRE
              Horm Res Paediatr
              10.1159/issn.1663-2818
              Hormone Research in Paediatrics
              S. Karger AG
              1663-2818
              1663-2826
              2002
              2002
              15 May 2002
              : 57
              : 3-4
              : 113-119
              Affiliations
              Growth Hormone and Related Substances Utilization Advisory Council, Catalan Health Service, Barcelona, Spain
              Article
              57961 Horm Res 2002;57:113–119
              10.1159/000057961
              12006707
              © 2002 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Tables: 5, References: 25, Pages: 7
              Categories
              Original Paper

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